77199-24-7Relevant academic research and scientific papers
Synthesis of the 2H-quinolizin-2-one scaffold via a stepwise acylation-intramolecular annulation strategy
Natarajan, Swaminathan R.,Chen, Meng-Hsin,Heller, Stephen T.,Tynebor, Robert M.,Crawford, Ellen M.,Minxiang, Cui,Kaizheng, Han,Dong, Jingchao,Hu, Bin,Hao, Wu,Chen, Shu-Hui
, p. 5063 - 5067 (2006)
A rapid entry into the 2H-quinolizin-2-one starting from 2-alkyl pyridine has been developed. Initial deprotonation of a 2-alkyl pyridine followed by acylation with a β-TMS-propyonate derivative provides acyclic precursors that after deprotection undergoe
Catalytic Dearomatization Approach to Quinolizidine Alkaloids: Five Step Total Synthesis of (±)-Lasubine II
James, Michael J.,Grant, Niall D.,O'Brien, Peter,Taylor, Richard J. K.,Unsworth, William P.
supporting information, p. 6256 - 6259 (2016/12/23)
A series of high-yielding silver(I)-catalyzed cyclization reactions of pyridine-, isoquinoline-, and pyrazine-ynones are described. The operationally simple and mild reaction conditions are a significant improvement over previously reported thermal cycliz
