77202-45-0Relevant academic research and scientific papers
Substituted coumarins as ambident nucleophiles in one-pot hydrogenation/alkylation reaction
Petkova-Yankova, Nevena I.,Nikolova, Rositca D.
, p. 2627 - 2634 (2020)
The regioselectivity of a one-pot hydrogenation/alkylation reaction of coumarins 1a and 1b with series of alkyl halides has been elucidated as a complementary work to reaction of acylation with the same coumarins. Reaction conditions have provided formation of only C-alkylation products with good to high yield. The results from the experiments are of significant importance to predict reactivity of 3-substituted coumarins in different reaction conditions.
