77210-10-7

Usage

Uses

Used in Pharmaceutical Industry:
(5S)-5-(2-sulfanylpropan-2-yl)imidazolidine-2,4-dione is used as a potential therapeutic agent for the treatment of diabetes and related metabolic disorders. Its specific properties and potential uses would need to be further investigated through experimental studies and clinical trials to confirm its efficacy and safety in treating these conditions.

Upstream product

• 77176-17-1 (S)-3-Mercapto-3-methyl-2-ureido-butyric acid 
• 52-67-5 3,3-dimethyl-D-cysteine 

Downstream Products

• 7526-77-4 5-iso-propylidenehydantoin 

Relevant academic research and scientific papers

Search for pro-drug forms of D-penicillamine: Synthesis and metabolism of D-pen-hydantoin.

The existence of dihydropyrimidase possessing the ability to hydrolyse into hydantoic acids some hydantoins of D relative configuration has been pointed out in the literature. Owing to the identity of relative configuration between (R)-5-isopropylhydantoin and (S)-5(1-mercapto-1-methyl) ethylhydantoin (D-pen-hydantoin), the synthesis and metabolism study of the latter were undertaken to determine if D-penhydantoin could act as a pro-drug form of D-penicillamine. Various references compounds i.e. corresponding hydantoic acid, its disulfide and hydantoin disulfide were synthesized to perform a quantitative study of the metabolic profile of D-penhydantoin. The only metabolite detected in the urines of rat and rabbit was 5-isopropylidenehydantoin.