77228-66-1

Usage

InChI:InChI=1/C8H6BrClO3/c9-6-3-5(10)1-2-7(6)13-4-8(11)12/h1-3H,4H2,(H,11,12)

Upstream product

• 122-88-3 4-Chlorophenoxyacetic acid 
• 861064-59-7 2-carboxymethoxy-5-chloro-phenylmercury ⁽¹⁺⁾; chloride 
• 779328-99-3 tert-butyl (2-bromo-4-chlorophenoxy)acetate 
• 695-96-5 2-bromo-4-chlorophenol 
• 255908-57-7 (2-bromo-4-chloro-phenoxy)-acetic acid methyl ester 

Downstream Products

• 1240285-13-5 [4-chloro-2-(2-methoxyphenylethynyl)phenoxy]acetic acid 
• 1374302-99-4 C₈H₅BrCl₂O₂ 
• 1240285-14-6 {4-chloro-2-[(3-trifluoromethylphenyl)ethynyl]phenoxy}acetic acid 

Relevant academic research and scientific papers

Design and Synthesis of Novel 4-Hydroxyl-3-(2-phenoxyacetyl)-pyran-2-one Derivatives for Use as Herbicides and Evaluation of Their Mode of Action

In order to develop a novel herbicide containing the β-triketone motif, a series of 4-hydroxyl-3-(2-phenoxyacetyl)-pyran-2-one derivatives were designed and synthesized. The bioassay results showed that compound II15 had good pre-emergent herbicidal activity even at a dosage of 187.5 g ha-1. Moreover, compound II15 showed a broader spectrum of weed control when compared with a commercial herbicide 2,4-dichlorophenoxyacetic acid (2,4-D), and displayed good crop safety to Triticum aestivum L. and Zea mays Linn. when applied at 375 g ha-1 under pre-emergence conditions, which indicated its great potential as a herbicide. More importantly, studying the molecular mode of action of compound II15 revealed that the novel triketone structure is a proherbicide of its corresponding phenoxyacetic acid auxin herbicide, which has a herbicidal mechanism similar to that of 2,4-D. The present work indicates that the 4-hydroxyl-3-(2-phenoxyacetyl)-pyran-2-one motif may be a potential lead structure for further development of novel auxin-type herbicides.

PHENOXY ACETIC ACID DERIVATIVES

The present invention provides phenoxyacetic acid derivatives of Formula (I) for the treatment of CRTH2 related disorders and disease selected from asthma, atopic dermatitis and inflammatory dermatoses.