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Carboxyatractyloside is a natural product derived from the roots of the Atractylis gummifera plant. It is a potent inhibitor of the adenine nucleotide translocator (ANT), a key component of the mitochondrial permeability transition pore (mPTP). Carboxyatractyloside has been extensively studied for its ability to modulate cellular processes and has potential applications in various fields.

77228-71-8

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77228-71-8 Usage

Uses

Used in Pharmaceutical Industry:
Carboxyatractyloside is used as an activator of Ca2+-induced mPTP opening for studying the role of mPTP in various cellular processes and diseases. Its ability to modulate mPTP opening can provide insights into the development of therapeutic agents targeting mPTP-related disorders.
Carboxyatractyloside is also used as an ANT inhibitor to study the inhibition of oxidative phosphorylation in intact T98G glioma cells. This application helps researchers understand the role of ANT in cellular respiration and energy production, which can be crucial for developing treatments targeting energy metabolism in cancer cells and other diseases.

Biochem/physiol Actions

Carboxyatractyloside is a highly selective inhibitor of cytosolic side-specific mitochondrial ADP/ATP carrier; i.e. adenine nucleotide translocase (ANT); causes stabilization of the c conformation of ANT leading to permeability transition pore (PTP) opening, loss of mitochondrial membrane potential, and apoptosis.

Check Digit Verification of cas no

The CAS Registry Mumber 77228-71-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,7,2,2 and 8 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 77228-71:
(7*7)+(6*7)+(5*2)+(4*2)+(3*8)+(2*7)+(1*1)=148
148 % 10 = 8
So 77228-71-8 is a valid CAS Registry Number.

77228-71-8 Well-known Company Product Price

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  • Sigma

  • (C4992)  Carboxyatractyloside potassium salt  ≥98% (HPLC), from Xanthium sibiricum, solid

  • 77228-71-8

  • C4992-2MG

  • 1,687.14CNY

  • Detail

77228-71-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name Carboxyatractyloside tripotassium salt

1.2 Other means of identification

Product number -
Other names CARBOXYATRACTYLOSIDE POTASSIUM SALT

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:77228-71-8 SDS

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