77236-35-2

Basic information

• Product Name: cyclo(Trp-Lys-Thr-Phe-Pro-Phe)acetate
• Synonyms: cyclo(Trp-Lys-Thr-Phe-Pro-Phe)acetate
• CAS NO: 77236-35-2
• Molecular Formula: C₄₄H₅₄N₈O₇
• Molecular Weight: 806.94896
• Mol File: 77236-35-2.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 1197.5°C at 760 mmHg
• Flash Point: 678°C
• Appearance: /
• Density: 1.29g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.631
• CAS DataBase Reference: cyclo(Trp-Lys-Thr-Phe-Pro-Phe)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: cyclo(Trp-Lys-Thr-Phe-Pro-Phe)acetate(77236-35-2)
• EPA Substance Registry System: cyclo(Trp-Lys-Thr-Phe-Pro-Phe)acetate(77236-35-2)

Safety Data

• Hazardous Substances Data: 77236-35-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C44H54N8O7/c1-28(54)39(51-40(55)34(46)18-10-11-21-45)43(58)50-37(24-30-15-6-3-7-16-30)44(59)52-22-12-20-38(52)42(57)49-36(23-29-13-4-2-5-14-29)41(56)48-32(27-53)25-31-26-47-35-19-9-8-17-33(31)35/h2-9,12-17,19-20,26-28,32,34,36-39,47,54H,10-11,18,21-25,45-46H2,1H3,(H,48,56)(H,49,57)(H,50,58)(H,51,55)/t28-,32-,34+,36+,37+,38+,39+/m1/s1

Upstream product

• 87282-39-1 cyclo-(L-phenylalanyl-D-tryptophanyl-Nε-benzyloxycarbonyl-L-lysyl-L-threonyl-L-phenylalanyl-L-proline) 

Relevant articles and documents

Cyclic peptide synthesis with thioacids

(Figure Presented) C-Terminal amino acid 9-fluorenylmethylthioesters may be carried through Boc chemistry solution phase peptide synthesis sequences. After insertion of the final residue in the form of an Fmoc carbamate, treatment with piperidine releases a seco-peptide as a C-terminal thioacid that on treatment with Sanger's reagent undergoes cyclization to a cyclic peptide. Cyclic penta- and hexapeptides have been synthesized in this manner, as has a cyclic glycopeptide. Functional group compatibility with alcohols and carboxylic acids is demonstrated.

Cyclic and bridged cyclic somatostatin analogs useful as local anti-inflammatory agents

Cyclic and bridged cyclic somatostatin analogs have been found to be useful as local anti-inflammatory agents in the treatment of such conditions, as, for example, psoriasis, eczema, seborrhea, and other localized inflammatory and allergic conditions.