77245-39-7

Upstream product

• 4755-77-5 Ethyl oxalyl chloride 
• 2393-23-9 4-methoxy-benzylamine 

Downstream Products

• 352011-59-7 C₁₀H₁₂N₂O₃ 
• 1257542-09-8 C₁₇H₁₆N₄O₂ 
• 1257542-10-1 C₁₈H₁₈N₄O₃ 
• 1257542-11-2 C₁₇H₁₅FN₄O₂ 
• 1257542-18-9 C₁₃H₁₇N₃O₃ 
• 1257542-03-2 C₁₃H₁₇N₃O₃ 
• 77245-52-4 1-(4-Methoxy-benzyl)-1H-tetrazole-5-carboxylic acid [2-cyano-3-(4-methyl-piperazin-1-yl)-phenyl]-amide 
• 69213-38-3 N-[2-cyano-3-(1-piperidinyl)phenyl]1-(4-methoxyphenylmethyl)-1H-tetrazole-5-carboxamide 
• 77259-52-0 1-(4-Methoxy-benzyl)-1H-tetrazole-5-carboxylic acid (2-carbamoyl-3-dimethylamino-phenyl)-amide 
• 77245-51-3 1-(4-Methoxy-benzyl)-1H-tetrazole-5-carboxylic acid (2-cyano-3-dimethylamino-phenyl)-amide 
• 77245-50-2 1-(4-Methoxy-benzyl)-1H-tetrazole-5-carboxylic acid (2-cyano-3-ethylamino-phenyl)-amide 
• 77245-49-9 1-(4-Methoxy-benzyl)-1H-tetrazole-5-carboxylic acid (2-cyano-phenyl)-amide 
• 69243-72-7 1-[(4-methoxyphenyl)methyl]-N-(2-pyridinyl)-1H-tetrazole-5-carboxamide 
• 66492-66-8 1-(4-Methoxybenzyl)-1H-tetrazole-5-carbonyl chloride 

Relevant academic research and scientific papers

Practical synthesis of functionalized 1,5-disubstituted 1,2,4-triazole derivatives

A general approach for the synthesis of 1,5-disubstituted-1,2,4-triazole compounds is described. A series of new oxamide-derived amidine reagents can be accessed in excellent yield with minimal purification necessary. Typically, these amidine reagents are stable crystalline solids and in certain cases were found to exist in a cyclic form as determined by NMR spectroscopy. Under optimized conditions, the direct reaction of these prepared reagents with various hydrazine hydrochloride salts efficiently generates the target triazoles. Both aromatic and aliphatic hydrazines react readily with the amidine reagents under very mild reaction conditions, delivering desired 1,5-disubstituted-1,2,4-triazole derivatives in good yields.

TRIAZOLOPYRAZINONES AS PDE1 INHIBITORS

The present invention provides triazolopyrazinones as PDE1 inhibitors and their use as a medicament, in particular for the treatment of neurodegenerative disorders and psychiatric disorders.

SUBSTITUTED TRIAZOLECARBOXAMIDES

Substituted triazolecarboxamides A b s t r a c t The invention relates to substituted triazolecarboxamides of the formula (I) in which R1, R2, R3 and R4 are as defined in the description, to their use as crop treatment agents, in particular as herbicides,