77249-46-8

Upstream product

• 131946-57-1 1-phenyl-2-(4,4,6-trimethyl-5,6-dihydro-4H-[1,3]oxazin-2-yl)-ethanol 
• 102-92-1 Cinnamoyl chloride 
• 87094-78-8 (E)-2-(2-phenylethenyl)-1,3-dithiolane 
• 14371-10-9 (E)-3-phenylpropenal 
• 21087-29-6 trans-3-phenylprop-2-enyl chloride 
• 4392-24-9 Cinnamyl bromide 
• 103-26-4 Methyl cinnamate 
• 10568-31-7 <αα-2H2>cinnamyl alcohol 

Downstream Products

• 64543-49-3 (S,E)-3-phenylprop-2-en-1-ol-[1-²H] 
• 310903-45-8 (E)-1-[2H₁]-3-phenylprop-2-en-1-ol 
• 1312081-68-7 (S,E)-4-cyclohexyl-5-nitro-1-phenylpent-1-en-3-one 
• 93698-11-4 3-deuterio-1,3-diphenyl-1-propanone 
• 77249-47-9 trans 1-phenyl<3-(2)H>buta-1,3-diene 

Relevant academic research and scientific papers

Sulfur-controlled and rhodium-catalyzed formal (3 + 3) transannulation of thioacyl carbenes with alk-2-enals and mechanistic insights

A rhodium-catalyzed denitrogenative formal (3 + 3) transannulation of 1,2,3-thiadiazoles with alk-2-enals is achieved, producing 2,3-dihydrothiopyran-4-ones in moderate to excellent yields. An inverse KIE of 0.49 is obtained, suggesting the reversibility of the oxidative addition of thioacyl Rh(i) carbenes to alk-2-enals. The late-stage structural modifications of steroid compounds are realized. Moreover, our studies show that thioacyl carbenes have different reactivities to those of α-oxo and α-imino carbenes, and highlight the importance of heteroatoms in deciding the reactivities of heterovinyl carbenes.

SYNTHESIS OF DEUTERATED ALDEHYDES

Described are methods for preparing a deuterated aldehyde using N-heterocyclic carbene catalysts in a solvent comprising D2O. The methods may be used to convert a wide variety of aldehydes (e.g., aryl, alkyl, or alkenyl aldehydes) to C-1 deuterated aldehydes under mild reaction conditions without functionality manipulation.

One-Pot Synthesis of Deuterated Aldehydes from Arylmethyl Halides

A facile, one-pot approach for synthesizing deuterated aldehydes from arylmethyl halides was developed using D2O as the deuterium source. The efficient process is realized by a sequence of formation, H/D exchange, and oxidation of pyridinium salt intermediates. The mild and air-compatible reaction conditions enable efficient synthesis of diverse deuterated aldehydes with high deuterium incorporation.

Palladium-catalyzed reduction of acid chlorides to aldehydes with hydrosilanes

An efficient synthesis of aldehydes from acid chlorides with hydrosilanes as a reducing agent in the presence of a palladium catalyst has been achieved. A simple mixture of commercially available Pd(dba)2 and Mes 3P as a catalyst realized the reduction of various acid chlorides including aliphatic acid chlorides and a, P-unsaturated acid chlorides to the corresponding aldehydes in good to high yields under mild reaction conditions. Georg Thieme Verlag Stuttgart ? New York.