77251-85-5Relevant academic research and scientific papers
Cinnamic acid derived oxazolinium ions as novel cytotoxic agents.
Hedvati, Lilach,Nudelman, Abraham,Falb, Eliezer,Kraiz, Boris,Zhuk, Regina,Sprecher, Milon
, p. 607 - 616 (2007/10/03)
Substituted cinnamoyl chlorides, 11, were converted into (2-hydroxyethyl)-oxazolinium chlorides 14, N,N-bis-(2-chloroethyl)amides 16 and (2-chloroethyl)-oxazolinium chlorides 17. Although derivatives 14 which possess electron-donating substituents (Me or MeO) were more potent than those substituted by electron-withdrawing groups (NO(2), Cl or CF(3)), the difference in cytotoxic actin was not significant. Modification of the lipophilic character in a series of alkoxy-substituted derivatives 14 led to more active compounds, where 14t that possesses a 4-octyloxy-phenyl-substituent was the most potent and displayed cytotoxic activity in the microM range. It is assumed that the oxazolinium salts act as alkylating agents, and undergo nucleophilic attack on the methylene adjacent to the ring oxygen where the oxazolinium ring parallels the aziridinium ring intermediate found in classical alkylating agents.
Intra- and Intermolecular Photodimerization of Mesogenic Triphenylene Derivative having Cinnamate Groups: Effects of Orientation and Mobility of the Mesogenic Molecules on the Photoreaction Behavior
Kurihara, Seiji,Nonaka, Takamasa
, p. 39 - 46 (2007/10/02)
The photoreactivity of cinnamate groups attached to a triphenylene ring was investigated in terms of formation of oligomers by photodimerization between cinnamate groups.It was found that the triphenylene derivative, 2,3,6,7,10,11-hexa(4'-octadecyloxycinn
Study of Anisotropic Phase Transitions of Some New Mesogenic Esters: Methyl p-(p'-n-Alkoxycinnamoyloxy) benzoates
Lohar, J. M.,Mahsru, Urvashi
, p. 125 - 128 (2007/10/02)
A new series of mesogenic esters, methyl p-(p'-n-alkoxycinnamoyloxy) benzoates (n-alkyl = CH3 to C18H37) has been synthesized.These esters show variations in textures and transitions as the series is ascended.The first member of the series is homeotropically-mesomorphic while the second exhibits mesophase in monotropic condition.The third member shows enantiotropic nematic mesophase of homeotropic variation; the fourth, fifth and sixth members exhibit enantiotropic smectic and nematic mesophases at definite transition temperatures.Heptyl to octadecyl derivatives exhibit only smectic phase with definite transition to isotropic liquid.While all the nematic phases are homeotropic, the smectic mesophases show focal conic Grandjean plates with fan shape texture belonging to smectic-A type.The mesomorphic-isotropic transitions show a gradual fall with the increase in alkyl chain length; the mesomorphic region of fan shape structures with reference to temperature range, decreases as the number of carbon atoms increases.The mesomorphic range is quite wide and the thermal stabilities are correlated with the structural characteristics of the molecules.
