77278-37-6

Basic information

• Product Name: tert-butyl 4-(2,2,2-trifluoroacetyl)piperazine-1-carboxylate
• Synonyms: tert-butyl 4-(2,2,2-trifluoroacetyl)piperazine-1-carboxylate
• CAS NO: 77278-37-6
• Molecular Formula: C11H17F3N2O3
• Molecular Weight: 282.2594896
• Mol File: 77278-37-6.mol
• Article Data: 13

Chemical Properties

• Appearance: /
• CAS DataBase Reference: tert-butyl 4-(2,2,2-trifluoroacetyl)piperazine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 4-(2,2,2-trifluoroacetyl)piperazine-1-carboxylate(77278-37-6)
• EPA Substance Registry System: tert-butyl 4-(2,2,2-trifluoroacetyl)piperazine-1-carboxylate(77278-37-6)

Safety Data

• Hazardous Substances Data: 77278-37-6(Hazardous Substances Data)

Usage

General Description

Tert-butyl 4-(2,2,2-trifluoroacetyl)piperazine-1-carboxylate is a chemical compound with a molecular formula of C13H19F3N2O3. It is a derivative of piperazine, which is a heterocyclic amine used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. The compound has a tert-butyl group attached to the piperazine ring and a 2,2,2-trifluoroacetyl group attached to the nitrogen atom of the piperazine. This chemical is often used as a reagent in organic synthesis, particularly in the preparation of various pharmaceutical compounds. It is also used in the development of new drug candidates and in the study of biological processes.

Upstream product

• 383-63-1 ethyl trifluoroacetate, 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 
• 76-05-1 trifluoroacetic acid 
• 354-32-5 trifluoracetyl chloride 
• 407-25-0 trifluoroacetic anhydride 

Downstream Products

• 245487-45-0 N-trifluoroacetyl piperazine hydrochloride 
• 1391636-30-8 C₁₇H₂₀ClF₃N₂O₃ 
• 1260098-31-4 2,2,2-trifluoro-1-[4-(2-{4-[3-((R)-2-methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-2-oxo-ethyl)-piperazin-1-yl]-ethanone 
• 13349-90-1 1-(2,2,2-trifluoroethyl)piperazine 
• 1252765-77-7 2,2,2-trifluoro-1-(4-(1-(1-(4-fluorophenyl)-1H-indole-5-carbonyl)azetidin-3-yl)piperazin-1-yl)ethanone 
• 1252779-85-3 1-[4-(1-benzhydrylazetidin-3-yl)piperazin-1-yl]-2,2,2-trifluoroethanone 
• 6511-88-2 2,2,2-trifluoro-1-(piperazine-1-yl)ethane-1-one 
• 692058-21-2 4-(2,2,2-trifluoroethyl)piperazin-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

ANTIMICROBIAL COMPOUNDS AND METHODS

The invention is directed to compounds that are active as antibacterial agents. The invention compounds are active against gram-positive and gram-negative bacteria and can be used to treat infections caused by gram-positive and gram-negative bacteria. Also disclosed are processes and intermediates for making the compounds.

Aryl alkynyl hydrocarbon compound and preparation method and application thereof

The invention relates to an aryl alkynyl hydrocarbon compound and a medicine compound containing the compound. The compound or the medicine compound can serve as an inhibitor of Retinoid-related orphan receptor gamma t (RORyt). The invention further relates to a method for preparing the compound and the medicine compound and application thereof to mammal treatment or prevention, especially RORyt mediated inflammation of humans or autoimmune diseases.

MONOACYLGLYCEROL LIPASE INHIBITORS FOR THE TREATMENT OF METABOLIC DISEASES AND RELATED DISORDERS

Disclosed are compounds, compositions and methods for treating metabolic diseases, including obesity and diabetes, and for reducing weight gain. Such compounds are represented by formula (I) as follows: wherein Y and Z are defined herein.