77278-57-0Relevant articles and documents
Sulfonamides incorporating piperazine bioisosteres as potent human carbonic anhydrase I, II, IV and IX inhibitors
Chiaramonte, Niccolò,Bua, Silvia,Angeli, Andrea,Ferraroni,Picchioni, Ilaria,Bartolucci, Gianluca,Braconi,Dei, Silvia,Teodori, Elisabetta,Supuran, Claudiu T.,Romanelli, Maria Novella
, (2019/08/01)
Starting from the molecular simplification of (R) 4-(3,4-dibenzylpiperazine-1-carbonyl)benzenesulfonamide 9a, a compound endowed with selectivity for human Carbonic Anhydrase (hCA) IV, a series of piperazines and 4-aminopiperidines carrying a 4-sulfamoylb
Synthesis and preclinical evaluation of [11C]MA-PB-1 for in?vivo imaging of brain monoacylglycerol lipase (MAGL)
Ahamed, Muneer,Attili, Bala,van Veghel, Daisy,Ooms, Maarten,Berben, Philippe,Celen, Sofie,Koole, Michel,Declercq, Lieven,Savinainen, Juha R.,Laitinen, Jarmo T.,Verbruggen, Alfons,Bormans, Guy
, p. 104 - 113 (2017/05/10)
MAGL is a potential therapeutic target for oncological and psychiatric diseases. Our objective was to develop a PET tracer for in?vivo quantification of MAGL. We report [11C]MA-PB-1 as an irreversible MAGL inhibitor PET tracer. The in?vitro inh