77278-62-7

Basic information

• Product Name: 1-PIPERAZINECARBOXYLIC ACID, 4-(2-PYRIDINYL)-, 1,1-DIMETHYLETHYL ESTER
• Synonyms: 1-PIPERAZINECARBOXYLIC ACID, 4-(2-PYRIDINYL)-, 1,1-DIMETHYLETHYL ESTER;TERT-BUTYL 4-PYRIDIN-2-YLPIPERIDINE-1-CARBOXYLATE;tert-butyl 4-(pyridin-2-yl)piperazine-1-carboxylate;1-Boc-4-(2-pyridinyl)-piperazine
• CAS NO: 77278-62-7
• Molecular Formula: C₁₄H₂₁N₃O₂
• Molecular Weight: 263.34
• Mol File: 77278-62-7.mol
• Article Data: 15

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-PIPERAZINECARBOXYLIC ACID, 4-(2-PYRIDINYL)-, 1,1-DIMETHYLETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 1-PIPERAZINECARBOXYLIC ACID, 4-(2-PYRIDINYL)-, 1,1-DIMETHYLETHYL ESTER(77278-62-7)
• EPA Substance Registry System: 1-PIPERAZINECARBOXYLIC ACID, 4-(2-PYRIDINYL)-, 1,1-DIMETHYLETHYL ESTER(77278-62-7)

Safety Data

• Hazardous Substances Data: 77278-62-7(Hazardous Substances Data)

Usage

Physical form

white solid substance

Molecular weight

294.36 g/mol

Use

in pharmaceutical research and as an intermediate in the synthesis of various pharmaceutical compounds

Value

unique molecular structure and properties make it valuable in the development of potential drug candidates and in medicinal chemistry research.

Upstream product

• 34803-66-2 1-(2-pyridyl)piperazine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 109-04-6 2-bromo-pyridine 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 
• 109-09-1 2-chloropyridine 
• 253175-46-1 3,3-dimethyl-1-piperazin-1-yl-butan-1-one 
• 110-86-1 pyridine 
• 77278-40-1 tert-butyl 4-(benzoyloxy)piperazine-1-carboxylate 

Downstream Products

• 497915-42-1 4-(5-iodopyridin-2-yl)piperazine-1-carboxylic acid tert-butyl ester 
• 34803-66-2 1-(2-pyridyl)piperazine 
• 1268865-67-3 methyl 3-(4-fluorophenyl)-2-(4-(pyridin-2-yl)piperazin-1-yl)quinoxaline-6-carboxylate 
• 1268862-77-6 3-(4-fluorophenyl)-2-(4-(pyridin-2-yl)piperazin-1-yl)quinoxaline-6-carboxylic acid 
• 1268865-14-0 methyl 2-phenyl-3-(4-(pyridin-2-yl)piperazin-1-yl)quinoxaline-6-carboxylate 
• 1268862-26-5 2-phenyl-3-(4-(pyridin-2-yl)piperazin-1-yl)quinoxaline-6-carboxylic acid 
• 52266-53-2 1-(pyridin-2-yl)-piperazine hydrochloride 

Relevant articles and documents

Highly Selective Sub-Nanomolar Cathepsin S Inhibitors by Merging Fragment Binders with Nitrile Inhibitors

Pharmacological inhibition of cathepsin S (CatS) allows for a specific modulation of the adaptive immune system and many major diseases. Here, we used NMR fragment screening and crystal structure-aided merging to synthesize novel, highly selective CatS inhibitors with picomolar enzymatic Ki values and nanomolar functional activity in human Raji cells. Noncovalent fragment hits revealed binding hotspots, while the covalent inhibitor structure-activity relationship enabled efficient potency optimization.

POLY-ADP RIBOSE POLYMERASE (PARP) INHIBITORS

The present invention is related to a pharmaceutical composition comprising a pharmaceutically acceptable carrier or diluent and a compound represented by the following structural formula: The present invention is also related a method of treating a subject with a disease which can be ameliorated by inhibition of poly(ADP-ribose)polymerase (PARP). The definitions of the variables are provided herein.

A tuned bicyclic proazaphosphatrane for catalytically enhanced n-arylation reactions with aryl chlorides

The N-arylation of various amines with aryl chlorides proceeded in good-to-excellent yields in the presence of P[N{(p-NMe2)C6H4CH2}CH2CH2]3N (1e, a new electron-rich proazaphosphatrane ligand) and small amounts of Pd2(dba)3 (dba = dibenzylideneacetone). This catalytic system was also very effective for the synthesis of carbazoles. An efficient palladium-catalyzed N-arylation reaction of amines under mild conditions with a tuned bicyclic proazaphosphatrane has been developed.