77280-41-2

Basic information

• Product Name: (1S)-6,7-Dimethoxy-1-methyl-2-(2-methyl-1-oxopropyl)-1,2,3,4-tetrahydroisoquinoline
• Synonyms: (1S)-6,7-Dimethoxy-1-methyl-2-(2-methyl-1-oxopropyl)-1,2,3,4-tetrahydroisoquinoline
• CAS NO: 77280-41-2
• Molecular Formula: C16H23NO3
• Molecular Weight: 277.3587
• Mol File: 77280-41-2.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 419.6°Cat760mmHg
• Flash Point: 207.5°C
• Appearance: /
• Density: 1.066g/cm³
• Vapor Pressure: 3.01E-07mmHg at 25°C
• Refractive Index: 1.515
• CAS DataBase Reference: (1S)-6,7-Dimethoxy-1-methyl-2-(2-methyl-1-oxopropyl)-1,2,3,4-tetrahydroisoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: (1S)-6,7-Dimethoxy-1-methyl-2-(2-methyl-1-oxopropyl)-1,2,3,4-tetrahydroisoquinoline(77280-41-2)
• EPA Substance Registry System: (1S)-6,7-Dimethoxy-1-methyl-2-(2-methyl-1-oxopropyl)-1,2,3,4-tetrahydroisoquinoline(77280-41-2)

Safety Data

• Hazardous Substances Data: 77280-41-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C16H23NO3/c1-10(2)16(18)17-7-6-12-8-14(19-4)15(20-5)9-13(12)11(17)3/h8-11H,6-7H2,1-5H3

Upstream product

• 79-30-1 isobutyryl chloride 
• 493-48-1 (6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline) 

Relevant articles and documents

Synthesis of isoquinoline alkaloid, (±)-salsolidine, using thiazolino[2,3-a]isoquinolinone S-oxide as intermediate

Thiazolino[2,3-a]isoquinolinones have been oxidized to the corresponding S-oxides and their 10b-methyl derivatives desulfurized with Raney nickel to give (±) N-acyl salsolidine. Base-catalyzed hydrolysis of the N-acetyl derivative afforded (±)-salsolidine. C-Methylation reactions of the title heterocyclic system have been investigated throughly. Stereochemistry of the synthesized compounds has been established.