77281-80-2

Upstream product

• 10071-38-2 6-Chloro-2-methyl-2H-pyridazin-3-one 
• 87199-17-5 4-formylphenylboronic acid, 

Downstream Products

• 919110-16-0 6-[4-((S)-4-(1-benzenesulfonyl-5-chloro-1H-indole-2-sulfonyl)-2-methyl-6-oxopiperazin-1-ylmethyl)-phenyl]-2-methyl-2H-pyridazin-3-one 
• 919110-12-6 6-(4-(S)-(4-(1-benzenesulfonyl-3-chloro-1H-indole-6-sulfonyl)-2-methyl-6-oxopiperazin-1-ylmethyl)-phenyl)-2-methyl-2H-pyridazin-3-one 
• 919110-10-4 ((S)-2-(2-chloroacetyl)-(4-(1-methyl-6-oxo-1,6-dihydropyridazin-3-yl)-benzylamino)-propyl)-carbamic acid tert-butyl ester 
• 1056481-02-7 N-((S)-2-amino-1-methylethyl)-2-chloro-N-[4-(1-methyl-6-oxo-1,6-dihydropyridazin-3-yl)-benzyl]-acetamide 
• 919110-11-5 2-methyl-6-[4-((S)-2-methyl-6-oxopiperazin-1-ylmethyl)-phenyl]-2H-pyridazin-3-one 
• 919110-13-7 (2-(4-(1-methyl-6-oxo-1,6-dihydropyridazin-3-yl)-benzylamino)-ethyl)-carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

HETEROCYCLIC SULFONAMIDE DERIVATIVES AS INHIBITORS OF FACTOR XA

The invention relates to compounds of formula (I), wherein R1, R2 and R3 are independently selected from carbon and nitrogen, and where at least one of R1, R2 and R3 is nitrogen; A is a single bond or a double bond; n is 0, 1, 2 or 3; each R4 is independently selected from hydrogen, C1-3 alkyl, hydroxy, oxo and thioxo; R5 is hydrogen or oxo; m is 0, 1, 2 or 3; each R6 is independently selected from hydrogen, C1-5alkyl, oxo, carboxy, cyano, tetrazolyl, hydroxy C1-5 alkyl, carboxy C1-5 alkyl, C1-5 alkylcarboxy, C1-5alkoxyoxo C1-5 alkyl, carbamoyl, C1-5 alkylcarbamoyl, di(C1-5 alkyl) carbamoyl, -CONR80 (CH2)xS(O)pR9, -CONH(CH2)qNR10R11, -C1-5 alkyl-Y1, -COOCHR17R18 and -CON R17 R18; R7 is carbon or nitrogen; p1 is 0, 1 or 2; each R8 is independently selected from hydrogen and halogen; or a pharmaceutically acceptable salt thereof, said compounds possess antithrombotic and anticoagulant properties and are accordingly useful in methods of treatment of humans or animals. The invention also relates to processes for the preparation of the compounds, to their use, to pharmaceutical compositions comprising them, to their use in the manufacture of medicaments for use in the production of an antithrombotic or anticoagulant effect, and to combinations comprising them.

HETEROCYCLIC SULFONAMIDE DERIVATIVES AS INHIBITORS OF FACTOR XA

The invention relates to compounds of formula (I), Chemical formula should be inserted here. Please see paper copy wherein R1 is hydrogen, C1-3alkyl, R5R6 aminoC1-5alkyl, where R5 and R6 are each independently selected from hydrogen and C1-3alkyl, or R5 and R6 may, together with the nitrogen to which they are attached, form a five- or six-membered heterocyclic ring, where said heterocyclic ring has 0 or 1 additional heteroatom; n is 1 or 2; each R2 are independently selected from hydrogen, oxo and C1-3alkyl, R3 is an indolyl, and R4 a hydrogen or a halogen; or a pharmaceutically acceptable salt thereof, said compounds possess antithrombotic and anticoagulant properties and are accordingly useful in methods of treatment of humans or animals. The invention also relates to processes for the preparation of the compounds, to their use, to pharmaceutical compositions comprising them, to their use in the manufacture of medicaments for use in the production of an antithrombotic or anticoagulant effect, and to combinations comprising them.