77285-13-3Relevant academic research and scientific papers
The 'triamino-analogue' of methyl cholate; A facial amphiphile and scaffold with potential for combinatorial and molecular recognition chemistry
Broderick, Shay,Davis, Anthony P.,Williams, Robert P.
, p. 6083 - 6086 (2007/10/03)
The triamino steroid 2 is synthesized from cholic acid (1), and found to possess little tendency to aggregate at pH 5 - 6 in aqueous solution. 2 and/or related derivatives are expected to find use in the synthesis of receptors and combinatorial libraries, and as 'contrafacial amphiphiles' for drug delivery across cell membranes.
Introducing Δ11 unsaturation into steroid compounds
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, (2008/06/13)
A process for the introduction of Δ11 unsaturation into steroid compounds having a C-12 sulfonate ester group is described. Dehydrosulfonation is carried out by reacting the sulfonate with a hexaalkylphosphoric triamide. The process is particularly useful with steroid compounds that also contain a blocked C-7 hydroxy group. The process yields the 11-enate in preference to the 6,11-dienate. The yield of the process can be increased by carrying out the reaction in the presence of a weak base.
