77290-47-2

Upstream product

• 77306-52-6 2-Acetamino-2-(7-chlor-3-indolylmethyl)malonsaeure-dimethylester 
• 53924-05-3 7-chloro-1H-indole 
• 302-84-1 serin 
• 108-24-7 acetic anhydride 
• 77290-45-0 2-Acetamino-2-(2-formylethyl)malonsaeure-dimethylester 
• 77290-46-1 2-Acetylamino-2-{3-[(2-chloro-phenyl)-hydrazono]-propyl}-malonic acid dimethyl ester 

Downstream Products

• 153-97-9 7-chloro-D/L-tryptophan 
• 75102-74-8 7-chloro-D-tryptophan 
• 852391-55-0 (S)-N-acetyl-7'-chlorotryptophan 
• 153-97-9 7-Chlor-D-tryptophan 
• 153-97-9 7-chloro-L-tryptophan 
• 852391-20-9 (R)-5-((7-chloro-1H-indol-3-yl)methyl)-3-methylimidazolidine-2,4-dione 
• 852391-20-9 (S)-5-(7'-Chloro-1H-indol-3ylmethyl)-3-methyl-imidazolidine-2,4-dione 

Relevant academic research and scientific papers

Synthesis and biological evaluation of novel tryptoline derivatives as indoleamine 2,3-dioxygenase (IDO) inhibitors

Indoleamine 2,3-dioxygenase (IDO) plays a significant role in several disorders such as Alzheimer's disease, age-related cataracts and tumors. A series of novel tryptoline derivatives were synthesized and evaluated for their inhibitory activity against ID

Structure-activity relationship study of novel necroptosis inhibitors

Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling necrosis. It can be induced in a FADD-deficient variant of human Jurkat T cells treated with TNF-α. 5-(1H-Indol-3-ylmethyl)-2-thiohydantoins and 5-(1H-indol-3-ylmethyl)hydantoins were found to be potent necroptosis inhibitors (called necrostatins). A SAR study revealed that several positions of the indole were intolerant of substitution, while small substituents at the 7-position resulted in increased inhibitory activity. The hydantoin ring was also quite sensitive to structural modifications. A representative member of this compound class demonstrated moderate pharmacokinetic characteristics and readily entered the central nervous system upon intravenous administration.

Synthesis of 7-Chloro-L- and 7-Chloro-D-tryptophan; Biosynthesis of Pyrrolnitrin

The article describes the synthesis of 7-chloro-DL-tryptophan (1 with R=Cl) via the intermediates 5, 6, 7 and 8.The separation of the optical antipodes was achieved by treatment of 7-chloro-N-chloroacetyl-DL-tryptophan (9) with carboxypeptidase.DL-Tryptophan (1 with R=H), 1 with R=Cl and its anomers, 1a with R=Cl and 1b with R=Cl, are substrates of L-tryptophan-2,3-dioxygenase from Pseudomonas aureofaciens.