77294-13-4

Upstream product

• 917-64-6 methyl magnesium iodide 
• 3874-54-2 4-(4-fluorophenyl)-4-oxo-n-butyl chloride 

Downstream Products

• 77294-15-6 1-p-Fluorophenyl-1-methyl-4-chloro-1-butene 
• 77294-01-0 2-[(E)-4-(4-Fluoro-phenyl)-pent-3-enyl]-1,2,3,4,6,7,12,12a-octahydro-pyrazino[1',2':1,6]pyrido[3,4-b]indole 

Relevant academic research and scientific papers

Agents Acting on CNS: Part XXX - Synthesis of 2-Substituted 1,2,3,4,6,7,12,12a-Octahydropyrazinopyrido-indoles

A number of 2-substituted pyrazinopyridoindoles (3,6-12) have been prepared by the condensation of 1,2,3,4,6,7,12,12a-octahydropyrazinopyridoindole (1) with appropriate halogen compounds.Treatment of 1 with ethylene oxide gives 4 which on condensation with p-fluorobenzoyl chloride yields 5.The corresponding 2-γ-(p-fluorobenzoyl)propyl-6-oxo-octahydropyrazinopyridoindole (14) is prepared by the oxidation of 1 with mercuric acetate followed by condensation of the resulting 6-oxo derivative (13) with γ-chloro-p-fluorobutyrophenone. 1-Oxo-2-substituted-pyrazinopyridoindoles (16-18) are prepared by the reaction of ethylene oxide on methyl 1,2,3,4-tetrahydropyridoindole-3-carboxylate followed by condensation of the resulting oxazino derivative (15) with amines.These compounds show tranquillizing, anti-inflammatory and diuretic activities.