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Usage

Uses

Used in Pharmaceutical Synthesis:
5-AMINO-2,3,3-TRIMETHYL-3H-INDOLE is used as a key intermediate in the synthesis of various pharmaceuticals for its potential to contribute to the development of new drugs with unique therapeutic properties. Its structural features allow for the creation of diverse chemical entities with potential applications in treating a range of medical conditions.
Used in Agrochemical Synthesis:
In the agrochemical industry, 5-AMINO-2,3,3-TRIMETHYL-3H-INDOLE is employed as a building block in the development of novel agrochemicals, such as pesticides and herbicides. Its chemical structure can be modified to create compounds with specific biological activities, targeting pests and weeds while minimizing harm to the environment and non-target organisms.
Used in Research and Development:
5-AMINO-2,3,3-TRIMETHYL-3H-INDOLE serves as a valuable research tool in the field of medicinal chemistry, where it is used to explore its potential biological activities and pharmacological properties. Researchers utilize 5-AMINO-2,3,3-TRIMETHYL-3H-INDOLE to investigate its interactions with biological targets, such as enzymes, receptors, and other proteins, to gain insights into its potential therapeutic applications and mechanisms of action.
Used in Medicinal Chemistry:
5-AMINO-2,3,3-TRIMETHYL-3H-INDOLE is of interest in medicinal chemistry due to its potential as a lead compound for the development of new therapeutic agents. Its unique chemical structure and potential biological activity make it a promising candidate for further optimization and modification to enhance its pharmacological properties and therapeutic efficacy.

Upstream product

• 3484-22-8 2,3,3-trimethyl-5-nitro-3H-indole 
• 60-29-7 diethyl ether 

Downstream Products

• 93272-84-5 5-amino-3,3-dimethyl-2-p-nitrostyryl-3H-indole 
• 1355342-75-4 C₃₀H₃₈N₃O⁽¹⁺⁾*Cl^(1-) 
• 93272-83-4 2,3,3-trimethyl-5-(p-nitrobenzylidene)amino-3H-indole 
• 97315-57-6 5-(4'-methoxybenzyloxy)benzylidenamine-2,3,3-trimethylindolenine 

Relevant academic research and scientific papers

NOVEL SQUARYLIUM COMPOUNDS, AND COMPOSITIONS COMPRISING SAME

The present disclosure is disclosed herein. The present invention relates to a novel squarylium compound and a near infrared absorbing resin composition containing the squarylium compound.

A highly sensitive fluorescent probe that quantifies transthyretin in human plasma as an early diagnostic tool of Alzheimer's disease

The development of sensitive and reliable fluorescent probes for the early diagnosis of Alzheimer's disease (AD) is highly challenging and plays an important role in achieving effective treatments. Herein, we designed and synthesized an indole-based fluorophore for TTR in human plasma, an important hallmark of AD pathogenesis. This robust and simple fluorescent method allows quantification of TTR in the complex biological matrix.

LABELS, THEIR PRODUCTION PROCESS AND THEIR USES

Labels are disclosed capable of forming a covalent or non-covalent bond with a target molecule, particularly a biological molecule. The structure of these labels may consist of a dye covalently bound by one or more carbons on its chemical structure to one or more [FUNC] group(s), and optionally one or more [SOL] group(s). The structure of these labels allow selection of dyes from a wide variety of different excitation and emission wavelengths and allow easy functionalization of the dye without appreciably altering its spectral characteristics or its solubility characteristics.

A simple FRET-based modular design for diagnostic probes

In recent years, there has been a massive effort to develop molecular probes with optical modes of action. Probes generally produce detectable signals based on changes in fluorescence properties. Here, we demonstrate the potential of self-immolative molecular adaptors as a platform for Turn-On probes based on the FRET technique. The probe is equipped with identical fluorophore pairs or a fluorophore/quencher FRET pair and a triggering substrate. Upon reaction of the analyte of interest with the triggering substrate, the self-immolative adaptor spontaneously releases the two dye molecules to break off the FRET effect. As a result, a new measurable fluorescent signal is generated. The fluorescence obtained can be used to quantify the analyte. The modular structure of the probe design will allow the preparation of various chemical probes based on the FRET activation technique.

NEW DYE COMPOUNDS

The present disclosure provides compounds that may be used as chromogens, fluorochromes, or as both. Said compounds may further be used as substrate for at least one enzyme, wherein said enzyme is capable of processing an aromatic amine group (—NH2), an aromatic hydroxyl group (—OH), or an aromatic phosphate group (—PO4). Furthermore, the present disclosure also provides methods for precipitating said compounds as well as methods for detecting a target using said compounds. Even further, kits comprising said compounds are disclosed. Said compounds may be used in any method utilizing a fluorochrome, a chromogen, or both.

Investigation of the Quasi-Liquid Crystal Structure

Quasi-lipid crystals, a metastable mesophase of thermochromic spiropyrans containing mesogenic groups, were investigated by different methods.Miscibility studies, X-ray diffraction, and UV-visible and FT-IR spectroscopy indicate that the material behaves basically as a nematic mesophase.Comparison of data of the present work with that obtained earlier by optical and ESR investigation of the behavior of fluorescent and paramagnetic probes results in the formulation of a structural model for quasi-liquid crystals.

INTERACTION OF 5-AMINO-2,3,3-TRIMETHYL-3H-INDOLE WITH p-NITROBENZALDEHYDE

The reaction of 5-amino-2,3,3-trimethyl-3H-indole with p-nitrobenzaldehyde may take place in two directions, depending on the temperature: with the formation of a Schiff's base or of the corresponding styryl compound.