77308-70-4

Upstream product

• 52094-29-8 (Z)-2-Methyl-3-(3-trifluoromethyl-phenyl)-but-2-enoic acid ethyl ester 
• 202664-53-7 2-fluoro-5-trifluoromethyl-acetophenone 

Downstream Products

• 344556-09-8 (Z)-2-Methyl-3-(3-trifluoromethyl-phenyl)-but-2-enoyl chloride 
• 77302-29-5 (Z)-2-Methyl-3-(3-trifluoromethyl-phenyl)-but-2-enoic acid cyclopropylamide 
• 77302-28-4 (Z)-2-Methyl-3-(3-trifluoromethyl-phenyl)-but-2-enoic acid amide 

Relevant academic research and scientific papers

Phenyl-substituted alkenylcarboguanidides carrying perfluoroalkyl groups, a process for their preparation, their use as a medicament or diagnostic agent, and also a medicament containing them

Phenyl-substituted alkenylcarboguanidides carrying perfluoroalkyl groups, a process for their preparation, their use as a medicament or diagnostic agent, and also a medicament containing them. Phenyl-substituted alkenylcarboguanidides carrying perfluoroalkyl groups, of the formula I in which the substituents have the meanings stated in the description, and their pharmaceutically suitable salts, are described. They are obtained by reacting a compound II with guanidine, in which R(1) to R(5) and R(A), R(B), R(C) and R(D) have the stated meaning, and L is a leaving group which easily undergoes nucleophilic substitution. Compounds I are excellent cardiovascular therapeutic agents.

Structure-activity relationship in cinnamamides. 3. Synthesis and anticonvulsant activity evaluation of some derivatives of (E)- and (Z)-m-(trifluoromethyl)cinnamamide

The (E)- and (Z)-m-(trifluoromethyl)-α,β-dimethylcinnamamides and some of their N-alkyl derivatives were prepared and pharmacologically tested as anticonvulsant agents in order to verify if a ring substituent, like the m-CF3 group, different from a halogen but possessing the same electronic effect could lead to equally active compounds. Some (E)-m-(trifluoromethyl)-α-methyl- and -non-methyl-substituted-cinnamamides were also prepared and tested. In the α,β-dimethyl series, the results show that the m-CF3 group leads to products more active than the ones unsubstituted on the phenyl ring but still less active than the p-halogen-substituted compounds previously studied. In the α-methyl and non-methyl-substituted series, the trend shows the m-CF3 group being able to produce less toxic and, in some cases, more active products than the previously studied amides.