773091-42-2Relevant academic research and scientific papers
Structure-based design of pyridopyrimidinediones as dipeptidyl peptidase IV inhibitors
Lam, Betty,Skene, Robert J.,Zhang, Zhiyuan,Stafford, Jeffery A.,Shi, Lihong,Gwaltney II, Stephen L.
, p. 6628 - 6631,4 (2012/12/12)
Dipeptidyl peptidase IV (DPP-4) inhibitors have been shown to enhance GLP-1 levels and thereby improve hyperglycemia in type II diabetes. From a small fragment hit, using structure-based design, we have discovered a new class of non-covalent, potent and s
RENIN INHIBITORS
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Page/Page column 41-42, (2010/06/16)
The invention provides compounds, pharmaceutical compositions, kits, method of preparing, and method of using the compounds which exhibit renin and other S9 proteases activities and consist of the formula:—wherein the variables are as defined herein.
