773139-56-3Relevant academic research and scientific papers
Preparation method of ethyl 5-chloro-2-fluoro-3-hydroxybenzoate
-
Paragraph 0024-0026; 0031-0033; 0036-0038, (2021/11/03)
The invention discloses a preparation method of ethyl 5-chloro-2-fluoro-3-hydroxybenzoate. The preparation method comprises the following steps of: (1) carrying out an esterification reaction on a compound 1 to obtain a compound 2; (2) carrying out a hydrocarbon boronation reaction on the compound 2 under the catalytic action of iridium to obtain a compound 3; and (3) carrying out a boric acid ester oxidation reaction on the compound 3 to obtain ethyl 5-chloro-2-fluoro-3-hydroxybenzoate. The method has the advantages of easily available raw materials, simple operation and high yield, and a single-target configuration product is obtained.
