77336-90-4

Upstream product

• 88-14-2 2-furanoic acid 
• 527-69-5 2-furancarbonyl chloride 
• 1147550-11-5 ammonium thiocyanate 
• 62-53-3 aniline 
• 26172-44-1 2-furoylisothiocyanate 
• 609-38-1 furan-2-carboxylic acid amide 
• 103-72-0 phenyl isothiocyanate 

Relevant academic research and scientific papers

Tunable Anticancer Activity of Furoylthiourea-Based RuII–Arene Complexes and Their Mechanism of Action

Fourteen new RuII–arene (p-cymene/benzene) complexes (C1–C14) have been synthesized by varying the N-terminal substituent in the furoylthiourea ligand and satisfactorily characterized by using analytical and spectroscopic techniques. Electrosta

Highly active copper(i) complexes of aroylthiourea ligands against cancer cells-synthetic and biological studies

The reaction of copper(i) bromide with aroylthiourea ligands (L) in the molar ratio 1?:?3 resulted in the formation of [CuBr(L)3]. The complexes were well characterized by analytical and spectroscopic (UV-visible, FT-IR, NMR and mass) technique

Addition–cyclization reactions of furan-2-carbonyl isothiocyanate with nitrogen nucleophiles as a synthetic route to novel azines and azoles of potential biological activity

Heterocyclization of furan-2-carbonyl isothiocyanate 1 with a variety of aliphatic and aromatic nitrogen nucleophiles resulted in the formation of a new series of heterocycles including triazines, pyrimidines, oxadiazines, imidazolidines, thiadiazoles and

Aroylthioureas: New organic ionophores for heavy-metal ion selective electrodes

Thiourea derivatives (46 aroylthioureas) having different substituents close to the sulfur atom were synthesized and their ionophore potential in ion selective electrodes (ISEs) was examined. Structural considerations were taken into account based on the corresponding heavy-metal ISE parameters. As ionophores, some 1-furoyl-3-substitnted thioureas (series 2) gave the best results in Pb(II), Hg(II) and Cd(II) ISEs. The strong intramolecular hydrogen bond in series 2 allows ligand interaction only through the C=S group. Substituents on the furan and phenyl rings give rise to low solubility in the membrane plasticizer. 3-Alkyl substituted furoylthioureas improve solubility but enhance oxidative processes with chain length. New X-ray diffraction (XRD) structures and theoretical DFT calculations were considered in the analysis of the substituent influence on the selectivity of ISEs. These new ionophores have advantages because of their stability, simple synthesis and easy modification of the sulfur binding ability resulting from substitution.

Phase transfer catalyzed synthesis of N-aryl-N′-(2-furoyl) thiourea derivatives

A series of N-aryl-N′-(2-furoyl)thiourea derivatives have been prepared in good to excellent yield under the conditions of solid-liquid phase transfer catalysis using polyethylene glycol-400 (PEG-400) as the catalyst.

INVESTIGATIONS IN THE SERIES OF ACYLTHIOUREAS. ACIDITY IN DIMETHYLFORMAMIDE

The pKa values of three series of substituted 1-furoyl- and 1-benzoyl-3-arylthioureas were determined in dimethylformamide.It was shown that the investigated acylthioureas are more acidic than pyridine-substituted thioureas and substituted thio

Reaction Behaviour of Amides with Carbondisulphide and Isothiocyanates

Reactions of substituted arylamides, hetarylamides and furylacrylicamide 1 with carbon disulphide present a possibility to synthesize imino-dithiocarbonic-S,S'-diester 5.The mechanism of the reaction and the reaction conditions are investigated.Quantum chemical investigations by simple HMO-method in connection with the experimental results describe the reaction in dependence upon the influence of substituent in 2- and 4-position to the phenylring.Further more is describe the reaction of amide with isothiocyanates to thiourea 6 and isothiourea 7. The structures of the final products are determined by analytical dates.