7734-92-1

Usage

Uses

Used in Pharmaceutical Industry:
5-methyl-(R)-(-)-Mellein and 5-methyl-(S)-(+)-Mellein are used as potential therapeutic agents for treating bacterial, fungal, and viral infections due to their weak antimicrobial activities.
Used in Research and Development:
These stereoisomers are utilized in research to study the effects of stereochemistry on biological activity and to develop more effective and selective drugs based on their structures.
Used in Drug Design and Synthesis:
5-methyl-(R)-(-)-Mellein and 5-methyl-(S)-(+)-Mellein can be used as starting materials or building blocks in the design and synthesis of new drugs with improved antimicrobial properties.
Used in Agriculture:
These stereoisomers may also be employed as biopesticides or fungicides to protect crops from bacterial, fungal, and viral infections, thereby reducing the need for chemical pesticides.

Upstream product

• 25045-36-7 2-methoxy-5-methylbenzoic acid 
• 24350-99-0 3,5-dimethyl-8-methoxy-3,4-dihydroisocoumarin 
• 7736-76-7 3,5-dimethyl-8-methoxy-3,4-dihydroisocoumarin 
• 88037-93-8 (R)-(-)-5-hydroxymethylmellein 

Relevant academic research and scientific papers

Isocoumarin derivative as well as preparation method and medical application thereof

The invention belongs to the technical field of chemical medicines, and relates to an isocoumarin compound of general formula (I) and a preparation method and medical application, of the isocoumarin compound in preparation of medicines for treating and mo

Discovery, synthesis, biological evaluation and molecular docking study of (R)-5-methylmellein and its analogs as selective monoamine oxidase A inhibitors

(R)-5-Methylmellein (5-MM), the major ingredient in the fermented mycelia of the medicinal fungus Xylaria nigripes (called Wuling Shen in Chinese)? was found to be a selective inhibitor against monoamine oxidase A (MAO-A) and might play an important role in the clinical usage of this edible fungus as an anti-depressive traditional Chinese medicine (TCM). Based on the discovery and hypothesis, a variety of (R)-5-MM analogs were synthesized and evaluated in vitro against two monoamine oxidase isoforms (MAO-A and MAO-B). Most synthetic analogs showed selective inhibition of MAO-A with IC50 values ranging from 0.06 to 29 μM, and compound 13aR is the most potent analog with high selectivity (IC50, MAO-A: 0.06 μM; MAO-B: >50 μM). Interestingly, the enzyme kinetics study of 13aR indicated that this ligand seemed to bind in the MAO-A active site according to so-called “tight-binding inhibition” mode. The molecular docking study of 13aR was thereafter performed in order to rationalize the obtained biological results.