77345-20-1Relevant articles and documents
STEREOSELECTIVE SYNTHESIS OF PIPERIDINE DERIVATIVES
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Page/Page column 14, (2010/06/22)
This invention relates to dialdehyde or dinitrile compounds, which are useful for stereoselective synthesis of piperidine, pyrrolidine, and azepane derivatives.
Design, synthesis, and preliminary pharmacological evaluation of N-Acyl-3-aminoglutarimides as broad-spectrum chemokine inhibitors in vitro and anti-inflammatory agents in vivo
Fox, David J.,Reckless, Jill,Warren, Stuart G.,Grainger, David J.
, p. 360 - 370 (2007/10/03)
A series of N-substituted 3-aminoglutarimides have been synthesized and tested for inhibitory activity against a range of chemokines in vitro and for suppression of lipopolysaccharide-induced inflammation in vivo. The results show that they represent the first class of small molecules with broad-spectrum chemokine inhibitory effects. Among the compounds studied, 10 (NR58,4) was the most potent, being active at doses between 5 and 15 nM in vitro and at 0.3 mg kg-1 in vivo.
Chemical synthesis and adjuvant activity of N-Acetylmuramyl-L-alanyl-D-isoglutamine (MDP) analogs
Kamisango,Saiki,Tanio,Kobayashi,Fukuda,Sekikawa,Azuma,Yamamura
, p. 1644 - 1654 (2007/10/02)
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