77345-20-1Relevant academic research and scientific papers
STEREOSELECTIVE SYNTHESIS OF PIPERIDINE DERIVATIVES
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Page/Page column 14, (2010/06/22)
This invention relates to dialdehyde or dinitrile compounds, which are useful for stereoselective synthesis of piperidine, pyrrolidine, and azepane derivatives.
Synthesis of peptidoglycan units with UDP at the anomeric position
Lioux, Thierry,Busson, Roger,Rozenski, Jef,Nguyen-Disteche, Martine,Frere, Jean-Marie,Herdewijn, Piet
, p. 1615 - 1641 (2007/10/03)
A series of UDP-disaccharide peptide compounds were synthesized as synthetic substrate analogues or potential inhibitors of glycosyl transferase. Fluorescent compounds have been prepared with the aim of developing a screening method for selecting transglycosylase inhibitors.
Design, synthesis, and preliminary pharmacological evaluation of N-Acyl-3-aminoglutarimides as broad-spectrum chemokine inhibitors in vitro and anti-inflammatory agents in vivo
Fox, David J.,Reckless, Jill,Warren, Stuart G.,Grainger, David J.
, p. 360 - 370 (2007/10/03)
A series of N-substituted 3-aminoglutarimides have been synthesized and tested for inhibitory activity against a range of chemokines in vitro and for suppression of lipopolysaccharide-induced inflammation in vivo. The results show that they represent the first class of small molecules with broad-spectrum chemokine inhibitory effects. Among the compounds studied, 10 (NR58,4) was the most potent, being active at doses between 5 and 15 nM in vitro and at 0.3 mg kg-1 in vivo.
Structure-Activity Studies on the C-Terminal Hexapeptide of Substance P with Modifications at the Glutaminyl and Methioninyl Residues
Poulos, Constantine,Stavropoulos, George,Brown, John R.,Jordan, Christopher C.
, p. 1512 - 1515 (2007/10/02)
Analogues of 6>-SP6-11 have been synthesized in which the SCH3 group of the Met11 side chain is replaced by other functional groups, such as (CH2)2NH2, COOH, CONH2, and COOR, which have basic, acidic, or neutral charac
