77355-03-4

Upstream product

• 4549-32-0 1,8-dibromooctane 
• 123-08-0 4-hydroxy-benzaldehyde 

Downstream Products

• 16834-64-3 3-(4-{8-[4-(2,2-Bis-ethoxycarbonyl-vinyl)-phenoxy]-octyloxy}-phenyl)-2-ethoxycarbonyl-acrylic acid ethyl ester 
• 1432480-37-9 (2E,2E)-3,3-(4,4-(octane-1,8-diylbis(oxy))bis(4,1-phenylene))bis(1-phenylprop-2-en-1-one) 
• 87367-83-7 2-(4-{8-[4-(1,2-Dicarboxy-ethyl)-phenoxy]-octyloxy}-phenyl)-succinic acid 
• 87367-96-2 C₂₈H₃₂N₂O₆ 

Relevant academic research and scientific papers

Synthesis, Molecular Docking Studies, and Anticonvulsant Evaluation of Novel bis-Phenylhydrazones against Chemically induced Seizures in Mice

A series of novel bis-phenylhydrazones were synthesized by the condensation of dialdehydes with phenylhydrazine to evaluate them for their anticonvulsant activity. Efficacy of newly synthesized compounds against pentylenetetrazole (PTZ)-induced, strychnin

Synthesis and mesomorphic properties of new methylene-linked linear symmetrical liquid crystal dimers

A series of methylene-linked symmetrical liquid crystal dimers were synthesized. Their structures were confirmed by physicochemical techniques. Differential scanning calorimetry and polarizing optical microscopy verified the liquid crystal behaviors and t

Helical self-assemblies of segmented poly(phenylenevinylene)s and their hierarchical donor-acceptor complexes

We report aromatic π-stack-driven helical self-assemblies of segmented poly(phenylenevinylene)s and their hierarchical helical donor-acceptor assemblies with electron deficient molecules by a solvent-induced self-organization process. New segmented PPVs w

New bispyrazoline derivatives built around aliphatic chains: Synthesis, characterization and antimicrobial studies

The bispyrazolines 3a-3h built around the alkyl chains of varying lengths have been synthesized from the cyclization reactions of bischalcones with phenyl hydrazine. The bischalcones 2a-2h were obtained from the Claisen-Schmidt reactions of acetophenone w

Biological evaluation of bisbenzaldehydes against four Mycobacterium species

A series of bisbenzaldehydes and structurally related analogs, conveniently synthesized via microwave-assisted reactions, were evaluated in vitro against drug susceptible and multi-drug resistant Mycobacterium tuberculosis, against virulent Mycobacterium bovis, against Mycobacterium ulcerans and against two Mycobacterium avium subspecies. Among the 33 substances that were tested, compound 12, i.e. 4,4′-[1,12-dodecanediyl(oxy)]bisbenzaldehyde, emerged as the most promising hit. Its activity was further confirmed in an intracellular growth inhibition assay of M. tb in murine J774 A.1 macrophages. None of the compounds showed significant cytotoxicity on human C3A hepatocytes in a neutral red dye uptake assay and no genotoxicity or mutagenicity was observed as demonstrated by a VITOTOX test and confirmed with a comet assay.

Bis(oxyphenylene)benzimidazoles: A novel class of anti-Plasmodium falciparum agents

A small library of 26 2,2′-[alkane-α,ω- diylbis(oxyphenylene)]bis-1H-benzimidazoles has been prepared and evaluated against Giardia intestinalis, Entamoeba histolytica, Trypanosoma brucei rhodesiense, Trypanosoma cruzi, Leishmania donovani, and Plasmodium

Synthesis and thermal properties of twin dimers containing cyanostilbene groups as a mesogenic group

Twin dimers (TDs) with a different linking group (ester or ether) between the mesogenic group (cycmostilbene moiety) and the flexible spacer were synthesized to clarify the effect of the linking group on the mesomorphic properties. The sequence of the est

The syntheses of 4,4'-(1,n-dioxaalkane)-bisbenzaldehydes and 4,4'-(1,n- dioxaalkane)-bis(α-methoxy phenylacetic acids)

The syntheses of 4,4'-(1,n-dioxaalkane)-bis(α-methoxyphenylacetic acids) were conducted using a base-catalyzed reaction. The reactants were potassium hydroxide (or lithium hydroxide/lithium chloride), bromoform, methanol and 4,4'-(1,n-dioxaalkane)-bisbenz

Bisoxadiazolidine derivative

A bisoxadiazolidine dione derivative represented by the following general formula (I) or a pharmaceutically acceptable salt thereof, which is useful as an insulin sensitivity-increasing drug, and a pharmaceutical composition thereof. STR1 each represents a phenylene group L: (1) an oxygen, (2) a STR2 (3) a --S(O)n --, (4) a --CO--, (5) a STR3 (6) an alkylene group or an alkenylene group which may respectively be interrupted with an oxygen atom and/or a sulfur atom.

NEW MESOGENIC POLYETHERS DERIVED FROM BENZALAZINES

Four homologous series of flexible main-chain polyethers derived from benzalazines are reported.Enantiotropic nematic phases were found for three of the series.The influence of molecular structure on the mesomorphic properties has been studied.A comparati