77355-98-7

Basic information

• Product Name: 3-(cyanomethyl)-5-hydroxy-2'-deoxyuridine
• Synonyms: 3-(cyanomethyl)-5-hydroxy-2'-deoxyuridine
• CAS NO: 77355-98-7
• Molecular Weight: 283.241
• Mol File: 77355-98-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-(cyanomethyl)-5-hydroxy-2'-deoxyuridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(cyanomethyl)-5-hydroxy-2'-deoxyuridine(77355-98-7)
• EPA Substance Registry System: 3-(cyanomethyl)-5-hydroxy-2'-deoxyuridine(77355-98-7)

Safety Data

• Hazardous Substances Data: 77355-98-7(Hazardous Substances Data)

Upstream product

• 624-75-9 iodoacetonitrile 
• 5168-36-5 5-hydroxy-2'-deoxyuridine 

Relevant articles and documents

Synthesis and Antiviral Activity of 5--2'-deoxyuridine

To study the influence of substitution of CN for CCH in the anti-herpes virus nucleoside 5-(propynyloxy)-2'-deoxyuridine (1), 5--2'-deoxyuridine (2) was prepared.When the potassium salt of 5-hydroxy-2'-deoxyuridine was reacted with iodoacetonitrile in dry DMF, the bisalkylated product 3-(cyanomethyl)-5--2'-deoxyuridine (3) was the major product with a lesser amount of 3-(cyanomethyl)-5-hydroxy-2'-deoxyuridine (5) and only a trace amount of the desired product (2).In contrast, when 5-hydroxy-2'-deoxyuridine was alkylated in water in the presence of 1 equiv of KOH, compound 2 was the major product.In cultures of primary rabbit kindey (PRK) cells, compound 2 showed an anti-herpes virus activity that was comparable to that of 1 and ara-A.Compound 2 did not inhibit incorporation of 3H>dThd or 3H>dUrd into DNA of PRK cells; however, its anti-herpes virus activity was completely prevented upon the addition of either dThd or dUrd.