77367-72-7Relevant articles and documents
Synthesis and in vitro protozoocidal evaluation of novel diazabicyclic tropolone derivatives
Khrizman, Alexander,Slack, Rachel D.,Remsing, Richard C.,Little, Susan,Yardley, Vanessa,Moyna, Guillermo
, p. 569 - 576 (2007)
The synthesis and in vitro antiparasitic activity of twenty-seven novel diazabicycles based on tropolone ethers is presented. The compounds can be readily prepared by means of a high-yielding hetero Diels-Alder reaction using simple and readily available starting materials. Several of the new diazabicycles have in vitro activities against Trypanosoma cruzi, Leishmania donovani, Trypanosoma brucei rhodesiense, and chloroquine-resistant Plasmodium falciparum that are comparable or superior to those of currently employed protozoocidal agents.