77373-44-5

Usage

Structure

Complex structure with a thieno[2,3-d]pyrimidin-4(3H)-one core, a pyridine ring, and an ethyl group

Use

Commonly used in the field of pharmaceuticals and organic synthesis

Potential applications

Drug discovery and development

Biological activities

Exhibits anti-inflammatory, anti-cancer, and anti-microbial properties

Value

Valuable scaffold for the design and synthesis of novel therapeutic agents with improved pharmacological profiles

Research interest

Interesting target for medicinal chemistry research

Upstream product

• 100-54-9 pyridine-3-carbonitrile 
• 4507-13-5 ethyl 2-amino-5-ethylthiophene-3-carboxylate 

Relevant academic research and scientific papers

Synthesis and antimicrobial activity of novel 2-(pyridin-2-yl)thieno[2,3-d] pyrimidin-4 (3H)-ones

In the present study, some new 2-(pyridin-2-yl)thieno[2,3-d]pyrimidin-4(3H) -ones derivatives (IIa-o) were synthesized. The target compounds (IIa-o) were synthesized through the acid catalyzed condensation of 2-cyano, 3-cyano, and 4-cyano-pyridines with various 2-amino-3-carbethoxythiophenes (Ia-e). All thiophene derivatives were synthesized by Gewald reaction. The structures of the newly synthesized compounds were confirmed by UV-Visible, FT-IR, 1H-NMR, and mass spectral studies. All synthesized compounds were evaluated for their antimicrobial activity against various gram-positive and gram-negative bacterial and fungal strains. Amongst the synthesized compounds IIa, IIb, IId, IIe, and IIm were found to be active. TUeBITAK.

Reaction of Nitriles under Acidic Conditions. Part I. A General Method of Synthesis of Condensed Pyrimidines

Nitriles are known to give rise to salts of different compositions with halogen acids.Many of the reactions undergone by nitriles under the influence of halogen acids are, in many cases, assumed to proceed via the intermediate formation of highly reactive