77373-46-7

Basic information

• Product Name: 2-phenyl-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-amine
• Synonyms: [1]Benzothieno[2,3-d]pyrimidin-4-amine, 5,6,7,8-tetrahydro-2-phenyl-; 2-Phenyl-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-amine
• CAS NO: 77373-46-7
• Molecular Formula: C₁₆H₁₅N₃S
• Molecular Weight: 281.3754
• Mol File: 77373-46-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 418.6°C at 760 mmHg
• Flash Point: 207°C
• Density: 1.315g/cm³
• Vapor Pressure: 3.24E-07mmHg at 25°C
• Refractive Index: 1.717
• CAS DataBase Reference: 2-phenyl-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-phenyl-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-amine(77373-46-7)
• EPA Substance Registry System: 2-phenyl-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-amine(77373-46-7)

Safety Data

• Hazardous Substances Data: 77373-46-7(Hazardous Substances Data)

Upstream product

• 108-94-1 cyclohexanone 
• 100-47-0 benzonitrile 
• 109-77-3 malononitrile 
• 4651-91-6 3-cyano-2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene 

Relevant articles and documents

Exploring the scope of the Gewald reaction: Expansion to a four-component process

An efficient four-component reaction was developed to take advantage of the reactivity of the 2-aminothiophene-3-carbonitrile functionality, which is obtained during the classical three-component Gewald reaction. Various α-methylene bearing ketones were reacted with malononitrile, elemental sulfur, and aryl/heteroarylnitrile derivatives in t-BuOH/NaOH to afford 2-arylthieno[2,3-d]pyrimidin-4-amines in high yields. Preliminary studies revealed the photophysical properties of the products and their potential for use as metal sensors.

Microwave-assisted synthesis of 4-amino-2-arylthieno[2,3- d ]pyrimidines and their subsequent functionalization

New 4-amino-2-arylthieno[2,3-d]pyrimidines were synthesized by reacting 2-amino-3-cyanothiophenes and aryl nitriles under microwave irradiation. Functionalization of 4-amino group was made by acetic anhydride and several isocyanates. Georg Thieme Verlag S

Reaction of Nitriles under Acidic Conditions. Part I. A General Method of Synthesis of Condensed Pyrimidines

Nitriles are known to give rise to salts of different compositions with halogen acids.Many of the reactions undergone by nitriles under the influence of halogen acids are, in many cases, assumed to proceed via the intermediate formation of highly reactive