77382-97-9Relevant academic research and scientific papers
Synthesis of chiral 1,4,2-Oxazaphosphepines
Salgado-Escobar, Oscar,Chavelas-Hernández, Leticia,Domínguez-Mendoza, Blanca E.,Linzaga-Elizalde, Irma,Ordo?ez, Mario
, p. 13794 - 13813 (2015/09/21)
Synthesis and structural characterization of 1,4,2-oxazaphosphepines is described. The 1,4,2-oxazaphosphepines were obtained from reaction of chiral 1,3-benzoxazines with dichlorophenylphosphine or triethyl phosphite. The configuration of some of these co
Enantioselective Cyclopropanation of 1,1-Diphenylethylene and Diazoacetic Acid Ester with Copper Catalysts
Brunner, Henri,Miehling, Wolfgang
, p. 1237 - 1254 (2007/10/02)
Copper(II) compounds catalyze the reaction of 1,1-diphenylethylene with diazoacetic acid ethylester.The main product is 2,2-diphenylcyclopropane carboxylic acid ethylester.The formation of the carbene dimerization products fumaric and maleic acid diethylester can be suppressed by the continuous addition of diazoacetic ester to 1,1-diphenylethylene. 37 optically active ligands, partly new, were combined with copper(II)-acetate to give in-situ-catalysts.In five cases isolated copper complexes were used as catalysts.The best optical inductions in the formation of 2,2-diphenylcyclopropane carboxylic acid ethylester with up to 65.6percent ee were achived with Schiffbase ligands, which derive from salicylaldehyde and amino alcohols, obtained from amino acid esters and phenyl Grignard. - Keywords: Catalytic enantioselective cyclopropanation; Copper(II) catalysts; Optical induction.
Studies on Chiral Organo-Sulfur Compounds. I. Asymmetric Synthesis of Sulfoxides with Optically Active o-Aminoalkylphenol Derivatives
Hiroi, Kunio,Sato, Shuko,Kitayama, Ryuichi
, p. 3471 - 3485 (2007/10/02)
Several kinds of optically active o-aminoalkylphenols were prepared and used to develop asymmetric synthetic methods for chiral sulfoxides.The reaction of 2,3-dihydro-1,2,3-benzoxathiazine 2-oxides (derived from the o-aminoalkylphenols and thionyl chloride) with phenylmagnesium bromide, followed by treatment with alkyllithium, gave optically active sulfoxides with high enantiospecificity.Among several kinds of optically active o-aminoalkylphenols examined, the readily available aminophenol, (S)-(-)-o-phenol, was found to be the most efficient and recyclable chiral source for the asymmetric synthesis of sulfoxides.Keywords - asymmetric synthesis; chiral sulfoxide; o-aminoalkylphenol; 3,4-dihydro-1,2,3-benzoxathiazine 2-oxide; thionyl chloride
