77397-92-3Relevant academic research and scientific papers
Studies on the Terpenoids and Related Alicyclic Compounds. XXI. Formation and X-Ray Crystal Structure of a Novel Spiro Dimer of 6-Dehydroxysantoninic Acid
Yamakawa, Koji,Nishitani, Kiyoshi,Murakami, Akihiro,Iitaka, Yoichi
, p. 3244 - 3250 (2007/10/02)
Treatment of 14-bromo-6-dehydroxysantoninic acid (1a) with 10percent Na2CO3-acetone solution gave the lactone dimer (2), the spiro dimer (5), and a hydroxy compound (4), in 17percent, 40percent, and 21percent yields, respectively.The molecular structure of the major product, 6-dehydroxysantoninic acid spiro dimer (5), was confirmed by X-ray crystallographic analysis.The mechanism of formation of 5 during the course of this reaction is discussed.Keywords - sesquiterpene; santonin derivatives; NMR; X-ray analysis; HOMO/LUMO reaction mechanism; dimerization
