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Usage

Uses

Used in Coordination Chemistry:
5-BROMO-[2,3']-BIPYRIDINE is used as a building block for the synthesis of coordination complexes. Its role in this application is crucial due to its ability to form stable metal complexes, which are of interest in the field of coordination chemistry.
Used in Catalysis:
In the Catalysis Industry, 5-BROMO-[2,3']-BIPYRIDINE is used as a component in the development of catalysts. The metal complexes formed using 5-BROMO-[2,3']-BIPYRIDINE can act as catalysts in various chemical reactions, enhancing the efficiency and selectivity of these processes.
Used in Material Science:
5-BROMO-[2,3']-BIPYRIDINE is utilized as a precursor in the creation of new materials with unique properties. The metal complexes derived from 5-BROMO-[2,3']-BIPYRIDINE can be integrated into materials that have potential applications in areas such as electronics, photonics, and nanotechnology.
Used in Medicinal Chemistry:
In the Pharmaceutical Industry, 5-BROMO-[2,3']-BIPYRIDINE is employed as a reagent in the synthesis of bioactive molecules. The metal complexes formed with 5-BROMO-[2,3']-BIPYRIDINE can possess medicinal properties, making them candidates for drug development.
Used in Analytical and Bioimaging Applications:
5-BROMO-[2,3']-BIPYRIDINE is used as a component in the development of fluorescent sensors and probes. Its fluorescence properties make it suitable for applications in analytical chemistry and bioimaging, where it can be used to detect and visualize specific molecules or biological processes.

Upstream product

• 624-28-2 2,5-dibromopyridine 
• 89878-14-8 3-Diethylboranylpyridine 
• 626-55-1 3-Bromopyridine 
• 223463-13-6 2-iodo-5-bromopyridine 
• 1692-25-7 3-pyridylboronic acid 
• 220565-63-9 pyridin-3-ylzinc(II) bromide 

Downstream Products

• 1061149-87-8 5-p-tolyl-2,3'-bipyridine 
• 1314250-31-1 3-(2,3'-bipyridin-5-yl)aniline 
• 1314250-29-7 5-(4-methoxyphenyl)-2,3'-bipyridine 
• 1314250-33-3 methyl 4-(2,3'-bipyridin-5-yl)benzoate 
• 1264516-07-5 [2,3'-bipyridin]-5-ylboronic acid 
• 1260106-29-3 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3'-bipyridine 
• 254902-22-2 2-(3-pyridyl)-5-[6-(3-pyridyl)-3-pyridyl]pyridine 

Relevant academic research and scientific papers

Synthesis of Pyridoclax Analogues: Insight into Their Druggability by Investigating Their Physicochemical Properties and Interactions with Membranes

Pyridoclax is considered a promising anticancer drug, acting as a protein-protein interaction disruptor, with potential applications in the treatment of ovarian, lung, and mesothelioma cancers. Eighteen sensibly selected structural analogues of Pyridoclax

Imidazole derivatives, its pharmaceutical composition and use thereof

Imidazolone compounds, pharmaceutically acceptable salts, solvates, polymorphs or prodrugs thereof are disclosed. Pharmaceutical compositions comprising above substances and uses for preventing and treating protein kinases related diseases, such as cancers, metabolic diseases, cardiovascular diseases and the like, are also disclosed.

Compound containing quinoxaline and pyridine groups and organic electroluminescent device thereof

The invention provides an organic electroluminescent compound containing quinoxaline and pyridine groups. The compound has better heat stability, high luminous efficiency and high luminous purity, can be used for manufacturing an organic electroluminescent device, and is applied to the field of organic solar cells, organic thin film transistors or organic photoreceptors. The invention also provides the organic electroluminescent device, which comprises an anode, a cathode and an organic layer, wherein the organic layer includes more than one layer in a luminous layer, a hole injection layer, a hole transporting layer, a hole blocking layer, and electron injection layer and an electron transporting layer; at least one layer in the organic layer contains a compound as shown by a structural formula I which is as shown in the description.

Molecular design of high-molecular-orientation electron-transport materials and application to organic light-emitting diodes

Two novel electron-transport materials (ETMs), 2,3′-Bpy- TP and 2,4′-Bpy-TP, with high horizontal molecular orientation to substrates, were synthesized. It was shown by measuring the IR absorption spectra of their deposited thin films that C-H N hydrogen bonds are formed between the 2,3′-Bpy-TP molecules and between the 2,4′-Bpy-TP molecules. It was also shown that there is a closed relationship between their molecular orientations and the driving voltages of electron-only devices (EODs) using them as electron-transport layers (ETLs).

Structural characterizations of oligopyridyl foldamers, α-helix mimetics

Protein-protein interactions are central to many biological processes, from intracellular communication to cytoskeleton assembly, and therefore represent an important class of targets for new therapeutics. The most common secondary structure in natural proteins is an α-helix. Small molecules seem to be attractive candidates for stabilizing or disrupting protein-protein interactions based on α-helices. In our study, we assessed the ability of oligopyridyl scaffolds to mimic the α-helical twist. The theoretical as well as experimental studies (X-ray diffraction and NMR) on conformations of bipyridines in the function of substituent and pyridine nitrogen positions were carried out. Furthermore, the experimental techniques showed that the conformations observed in bipyridines are maintained within a longer oligopyridyl scaffold (quaterpyridines). The alignment of the synthesized quaterpyridine with two methyl substituents showed that it is an α-helix foldamer; their methyl groups overlap very well with side chain positions, i and i + 3, of an ideal α-helix.

2-Pyridyl and 3-pyridylzinc bromides: direct preparation and coupling reaction

A facile synthetic approach to the direct preparation of 2-pyridyl and 3-pyridylzinc bromides has been demonstrated using Rieke zinc with 2-bromopyridine and 3-bromopyridine, respectively. A variety of different electrophiles have been coupled with the resulting organozinc reagents to give the corresponding cross-coupling products in moderate to good yields.

LINCOSAMIDE DERIVATIVE, AND ANTIBACTERIAL AGENT COMPRISING THE SAME AS ACTIVE INGREDIENT

An objective of the present invention is to provide compounds of formula (I) or their pharmacologically acceptable salts or solvates wherein A represents aryl while R1 represents a five- or six-membered monocyclic heterocyclic group, or A represents a four- to six-membered monocyclic heterocyclic group while R1 represents aryl or a five- or six-membered monocyclic heterocyclic group; R2 represents a hydrogen atom or C1-6 alkyl; R3 represents C1-6 alkyl or C3-6 cycloalkyl-C1-4 alkyl; R4, R5, and R6 represent a hydrogen atom; R7 represents C1-6 alkyl; and m is 1 to 3. The compounds are novel lincosamide derivatives that have a potent activity against resistant Streptococcus pneumoniae. Further, the compounds are usable as antimicrobial agents and are useful for preventing or treating bacterial infectious diseases.

A facile synthetic approach to the preparation of 3-pyridyl derivatives: Preparations and coupling reactions of 3-pyridylzinc and its analogues

A facile synthetic approach to the direct preparation of 3pyridylzinc bromide has been demonstrated using Rieke zinc with 3-bromopyridine in the presence of a catalytic amount of lithium chloride. A variety of different electrophiles have been coupled to give the corresponding cross-coupling products in moderate to good yields. Also, this methodology has been expanded to the preparation of the corresponding organozinc reagents of 3-bromopyridine analogues. Georg Thieme Verlag Stuttgart.

Synthesis of dihalo bi- and terpyridines by regioselective Suzuki-Miyaura cross-coupling reactions

This paper describes an efficient and regioselective synthetic route leading to new dihalobi- and terpyridines. We developed a strategy based on regioselective sequence of Suzuki-Miyaura cross-coupling reactions between bromopyridyl boronic acids and dihalopyridines and dihalobipyridines. The study of the influence of the nature and the position of the halogen atoms leads to prepare bromoiododerivatives to obtain good selectivities.