77400-65-8 Usage
Uses
Used in Pharmaceutical Industry:
Asocainol is used as an antiarrhythmic agent for treating cardiac arrhythmias. It works by blocking the sodium channels in the myocardial cell membrane, which helps to regulate the heart's electrical activity and restore normal rhythm.
Used in Research and Development:
Labelled Asocainol is used as a research tool for studying the mechanisms of action and potential applications of class I antiarrhythmic drugs. This can help in the development of new drugs and therapies for the treatment of cardiac arrhythmias and other related conditions.
Originator
Asocainol,ZYF Pharm
Manufacturing Process
A solution of a Grignard reagent is prepared from 5.5 g (0.23 mol) activated
magnesium turnings and 41.5 g (0.24 mol) phenethyl bromide in 200 ml
anhydrous diethyl ether. To this is added dropwise, at 35-40°C, a solution of
31.5 g (0.1 mol) thebaine in 0.4 liters dry benzene. After heating under reflux
for 2 hours, the reaction mixture is decomposed with a solution of 48 g
ammonium chloride in 200 ml water. The usual working up, after conversion
of the base into the hydrochloride by means of hydrogen chloride in ethyl
acetate, gives 7.3 g (21% of theory) (+/-)-2,12-dimethoxy-1-hydroxy-7-
methyl-6-phenethyl-5,6,8,9-tetrahydro-7H-dibenz[d,f]azonine hydrochloride,
melting point 227.6°C, after recrystallization from propan-2-ol.
Check Digit Verification of cas no
The CAS Registry Mumber 77400-65-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,7,4,0 and 0 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 77400-65:
(7*7)+(6*7)+(5*4)+(4*0)+(3*0)+(2*6)+(1*5)=128
128 % 10 = 8
So 77400-65-8 is a valid CAS Registry Number.
InChI:InChI=1/C27H31NO3/c1-28-16-15-20-10-13-23(30-2)18-24(20)26-21(11-14-25(31-3)27(26)29)17-22(28)12-9-19-7-5-4-6-8-19/h4-8,10-11,13-14,18,22,29H,9,12,15-17H2,1-3H3
