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Vasopressin, also known as des-Tyr(2-methyl)-4-Val-D-8-Arg-, is a synthetic analog of the naturally occurring hormone vasopressin, which plays a crucial role in regulating water balance and blood pressure in the body. This chemical is a cyclic nonapeptide that functions as a potent vasoconstrictor, meaning it narrows blood vessels and increases blood pressure. It is structurally similar to the native vasopressin but has been modified to enhance its stability and effectiveness. The modifications include the removal of the tyrosine residue at position 2, the substitution of valine for isoleucine at position 4, and the replacement of arginine with D-arginine at position 8. These alterations result in a molecule with a longer duration of action and increased resistance to enzymatic degradation compared to the natural hormone. Vasopressin analogs like des-Tyr(2-methyl)-4-Val-D-8-Arg- are used in various medical applications, such as treating conditions characterized by low blood pressure or excessive urination, due to their ability to constrict blood vessels and reduce urine output.

77403-95-3

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77403-95-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 77403-95-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,7,4,0 and 3 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 77403-95:
(7*7)+(6*7)+(5*4)+(4*0)+(3*3)+(2*9)+(1*5)=143
143 % 10 = 3
So 77403-95-3 is a valid CAS Registry Number.

77403-95-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name <1-(β-mercapto-β,β-cyclopentamethylenepropionic acid),2-(O-methyl)tyrosine,4-valine,8-D-arginine>vasopressin

1.2 Other means of identification

Product number -
Other names [1-(β-mercapto-β,β-cyclopentamethylenepropionic acid),2-(O-methyl)tyrosine,4-valine,8-D-arginine]vasopressin

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:77403-95-3 SDS

77403-95-3Upstream product

77403-95-3Downstream Products

77403-95-3Relevant academic research and scientific papers

Synthetic Antagonists of in Vivo Antidiuretic and Vasopressor Responses to Arginine-vasopressin

Manning, Maurice,Lammek, Bernard,Kolodziejczyk, Alexander M.

, p. 701 - 706 (2007/10/02)

Four analogues of vasopressin and four analogues of its L-arginine isomer d(CH2)5VAVP with O-methyl, O-ethyl, O-isopropyl and O-n-propyltyrosine substituents at p

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