77404-73-0Relevant academic research and scientific papers
New route to 2-(β-aminopropyl)-1,4-dimethoxybenzene
Yutilov,Malyutina,Shcherbina,Kirillova
, p. 1787 - 1792 (2007/10/03)
A new synthetic route was proposed and an original procedure developed for preparing 2-(β-aminopropyl)-1,4-dimethoxybenzene, which is an important intermediate in synthesis of a blue developing dye for color instant-picture process of the Polaroid type.
High pressure nucleophilic fluoride-ion substitution reactions: Formation of fluoroalkylbenzenes
Gerdes, John M.,Keil, Robert N.,Shulgin, Alexander T.,Mathis, Chester A.
, p. 121 - 129 (2007/10/03)
A series of 1-phenyl-2-tosyloxy- and 1-phenyl-3-tosyloxyalkanes was synthesized and then subjected to tetrabutylammonium fluoride in THF under 15 kbar (1.5 GPa), 8 kbar or 1 bar pressures. The resultant substitution and elimination reaction product distributions were analyzed. The application of pressure enhanced the progress of the fluoride-ion substitution reactions. The degree of selectivity of the one reaction over the other was found to be a function of tosylate substrate structure and the amount of pressure applied. The exclusive formation of fluoroalkanes from 1-phenyl-2-tosyloxyalkane substrates under 15 kbar pressure demonstrated the potential of the pressure method for prospective use in fluorine-18 radiolabelling applications.
