77405-69-7

Upstream product

• 42454-06-8 2-nitro-5-hydroxybenzaldehyde 
• 2746-25-0 p-Methoxybenzyl bromide 

Downstream Products

• 77405-77-7 4-(2-Benzyloxy-3,4-dimethoxy-phenyl)-6-(6-methoxy-5-nitro-quinolin-2-yl)-3-methyl-pyridine-2,5-dicarboxylic acid 2-methyl ester 
• 77405-76-6 4-(2-Benzyloxy-3,4-dimethoxy-phenyl)-6-(6-methoxy-5-nitro-quinolin-2-yl)-3-methyl-pyridine-2,5-dicarboxylic acid 
• 77405-75-5 4-(2-Benzyloxy-3,4-dimethoxy-phenyl)-6-formyl-2-(6-methoxy-5-nitro-quinolin-2-yl)-5-methyl-nicotinic acid 
• 77405-74-4 4-(2-Benzyloxy-3,4-dimethoxy-phenyl)-2-(6-methoxy-5-nitro-quinolin-2-yl)-5,6-dimethyl-nicotinic acid 
• 77405-71-1 2-[4-(2-Benzyloxy-3,4-dimethoxy-phenyl)-5,6-dimethyl-3-vinyl-pyridin-2-yl]-6-(4-methoxy-benzyloxy)-quinoline 
• 77405-79-9 5-Amino-6-(5-amino-6-methoxy-quinolin-2-yl)-4-(2-benzyloxy-3,4-dimethoxy-phenyl)-3-methyl-pyridine-2-carboxylic acid methyl ester 
• 77405-73-3 2-[4-(2-Benzyloxy-3,4-dimethoxy-phenyl)-5,6-dimethyl-3-vinyl-pyridin-2-yl]-6-methoxy-5-nitro-quinoline 
• 77405-72-2 2-[4-(2-Benzyloxy-3,4-dimethoxy-phenyl)-5,6-dimethyl-3-vinyl-pyridin-2-yl]-quinolin-6-ol 
• 77405-78-8 methyl 5-amino-4-<2-(benzyloxy)-3,4-dimethoxyphenyl>-6-(6-methoxy-5-nitro-2-quinolyl)-3-methylpyridine-2-carboxylate 
• 77418-04-3 4-(4-Methoxy-benzyloxy)-2-[(E)-p-tolylimino-methyl]-phenylamine 
• 77405-70-0 [1-[5-(4-Methoxy-benzyloxy)-2-nitro-phenyl]-meth-(Z)-ylidene]-p-tolyl-amine 

Relevant academic research and scientific papers

NOVEL CURCUMIN DERIVATIVE

To develop a highly safe measure to treat Alzheimer's disease using a secretase-inhibiting substance, there is provided a compound represented by the following general formula (I) or a salt thereof: wherein A represents a phenyl group or the like, R1 represents a chlorine atom, a bromine atom, or a nitro group or the like, R2, R3, R4, and R5 each represent a hydrogen atom or the like, and L represents CH2—CH2 or CH═CH.

NOVEL CURCUMIN DERIVATIVE

The present invention provides a novel compound that is structurally similar to curcumin and has a suppressive effect on Aβ aggregation, a degradative effect on Aβ aggregates, an inhibitory effect on β-secretase, and a protective effect on neurons. The novel compound is a compound represented by the following general formula (Ia) or a salt thereof: wherein R1 represents a 4-hydroxy-3-methoxyphenyl group or the like, and R2 represents a 1H-indol-6-yl group or the like.