77414-60-9

Upstream product

• 136-95-8 2-amino-benzthiazole 
• 2719-27-9 cyclohexanylcarbonyl chloride 
• 1141-88-4 2-Aminophenyl disulfide 

Downstream Products

• 77414-69-8 N-(cyclohexylmethyl)-2-aminobenzo[d]thiazole 
• 77427-39-5 C₁₉H₂₂N₂O₂S 

Relevant academic research and scientific papers

Fragment-based design of selective GPCR ligands guided by free energy simulations

Fragment-based drug discovery relies on successful optimization of weakly binding ligands for affinity and selectivity. Herein, we explored strategies for structure-based evolution of fragments binding to a G protein-coupled receptor. Molecular dynamics s

Synthesis of sulfur heterocycles via domino metal-mediated reactions

Two methodologies to access S-heterocycles and mixed N,S-heterocycles via metal-mediated domino reactions are described. One involves a cyclocarbopalladation/cross-coupling domino process and leads to benzene-fused five- or six-membered sulfur heterocycles with a stereo defined tetrasubstituted exocyclic double bond. The other consists in a three-component domino reaction between 2-aminophenyl disulfide, copper cyanide, and an electrophile to access N-substituted 2-amino benzothiazoles. Preliminary results in the use of the second method to access N-substituted 2-imino benzothiazoles are also reported.

Rapid Synthesis of Aryl Fluorides in Continuous Flow through the Balz–Schiemann Reaction

The Balz–Schiemann reaction remains a highly utilized means for preparing aryl fluorides from anilines. However, the limitations associated with handling aryl diazonium salts often hinder both the substrate scope and scalability of this reaction. To address this, a new continuous flow protocol was developed that eliminates the need to isolate the aryl diazonium salts. The new process has enabled the fluorination of an array of aryl and heteroaryl amines.

Aerobic Copper-Mediated Domino Three-Component Approach to 2-Aminobenzothiazole Derivatives

An unprecedented three-component reaction involving a 2,2′-diaminodiaryl disulfide, copper cyanide, and an electrophile is described. This transformation is based on an oxidative copper-mediated S-cyanation as a key step and involves a cyanation/cyclization/acylation domino sequence enabling a rapid and efficient synthesis of diversely substituted 2-aminobenzothiazole derivatives. Notably, this reaction proceeds via an original mechanism involving an intermolecular migration of the acyl group.

IMIDE-CONTAINING BENZOTHIAZOLE DERIVATIVE OR ITS SALT AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

The present invention provides an imide-containing benzothiazole derivative or its pharmaceutically acceptable salt, a process for the preparation thereof, and a pharmaceutical composition comprising the same. The imide-containing benzothiazole derivative or its pharmaceutically acceptable salt can selectively inhibit the protein-protein interaction between KRS and a laminin receptor (LR), thereby inhibiting migration of cancer cells. Therefore, the imide-containing benzothiazole derivative or its pharmaceutically acceptable salt may be usefully applied for preventing or treating the diseases associated with cancer cell metastasis.

Synthesis and biological evaluation of a series of (Benzo[d]thiazol-2-yl) cyclohexanecarboxamides and (Benzo[d]thiazol-2-yl)cyclohexanecarbothioamides

A series of benzothiazole derivatives including N-(benzo[d]thiazol-2-yl) cyclohexanecarboxamides (2a-g) and N-(benzo[d]thiazol-2-yl) cyclohexancarbothioamides (3b-d) have been synthesized and evaluated for cytotoxic and antimicrobial activities. Two compo