774214-89-0Relevant academic research and scientific papers
Efficient synthesis of an enantiopure thiasteroid by a double heck reaction
Tietze, Lutz F.,Luecke, Lars P.,Major, Felix,Mueller, Peter
, p. 635 - 640 (2004)
The thiaestrane 7 was synthesized by two sequential Heck reactions starting from the thiophene derivatives 8a-8c, which contain a (Z)-halogenovinyl group, and the enantiopure hydrindene 2a. The first intermolecular Pd-catalyzed reaction leads to 11a and 11b in a highly regio- and diastereoselective manner. A subsequent intramolecular Heck reaction catalyzed by the palladacycle 4 then gave the thiasteroid 7 with an unusual cis-junction of the rings B and C.
