77422-49-2

Upstream product

• 77431-74-4 (S)-2-{(S)-2-tert-Butoxycarbonylamino-3-[1-(diphenyl-pyridin-4-yl-methyl)-1H-imidazol-4-yl]-propionylamino}-3-phenyl-propionic acid methyl ester 
• 1620-30-0 diphenyl(pyridin-4-yl)methanol 
• 14548-46-0 4-Benzoylpyridine 
• 62982-21-2 N(α)-t-butoxycarbonyl-N(Im)-diphenyl-4-pyridylmethyl-L-histidine methyl ester 
• 64991-62-4 N(α)-t-butoxycarbonyl-N(Im)-diphenyl-4-pyridylmethyl-L-histidine 
• 64991-61-3 diphenyl(4-pyridyl)methyl chloride hydrochloride 

Relevant academic research and scientific papers

Amino-acids and Peptides. Part 45. The Protection of the Thiol Function of Cysteine and the Imidazole-N of Histidine by the Diphenyl-4-pyridylmethyl Group

S-(Diphenyl-4-pyridylmethyl)-L-cysteine (1) and its derivatives (2)-(7) have been prepared and used in peptide synthesis.In contrast to the analogous S-trityl group, this protection is stable in acid but it is cleaved readily by zinc-acetic acid, by mercury(II) acetate, by iodine, and by electrolytic reduction.N(Im)-Diphenyl-4-pyridylmethyl-L-histidine derivatives (9)-(13) are also reported; the protecting group is again stable to acid but cleaved by hydrogenolysis, by zinc-acetic acid, and by electrolytic reduction, and it has been used in the synthesis of L-histidyl-L-leucine, -L-phenylalanine, and -glycine.