774226-07-2Relevant academic research and scientific papers
Synthesis and anti-HIV activity of 4′-cyano-2′,3′ -didehydro-3′-deoxythymidine
Haraguchi, Kazuhiro,Itoh, Yoshiharu,Takeda, Shingo,Honma, Yosuke,Tanaka, Hiromichi,Nitanda, Takao,Baba, Masanori,Dutschman, Ginger E.,Cheng, Yung-Chi
, p. 647 - 654 (2007/10/03)
A new anti-HIV agent 4′-cyano-2′,3′-didehydro-3′ -deoxythymidine (9) was synthesized by allylic substitution of the 3′,4′-unsaturated nucleoside 14, having a leaving group at the 2′-position, with cyanotrimethylsilane in the presence of SnCl4. Evaluation
