77429-97-1

Upstream product

• 6331-00-6 N-(2-chloroethyl)-4-methylbenzenesulfonamide 
• 6367-75-5 2-(tosylamino)ethyl p-toluenesulfonate 
• 56187-04-3 1,4,7-tritosyl-1,4,7-triazaheptane 
• 111-40-0 3-azapentane-1,5-diamine 
• 98-59-9 p-toluenesulfonyl chloride 
• 3634-89-7 N-(p-toluenesulfonyl)aziridine 
• 14316-16-6 N-tosylethylenediamine 

Downstream Products

• 142738-83-8 N,N'-<(palmitoylnitrilo)bis(ethylene)>bis<4-toluenesulfonamide> 
• 164529-65-1 N,N'-{[(2-cyanoethyl)imino]di(ethane-2,1-diyl)}bis(4-methylbenzenesulfonamide) 
• 112193-79-0 N³-benzyl-N¹,N⁵-ditosyl-3-aza-1,5-pentanediamine 
• 77429-94-8 4,17-dibenzoyl-1,7,14,20-tetrakis(p-tolylsulfonyl)-1,4,7,14,17,20-hexaazacyclohexacosane 
• 77429-93-7 4,15-dibenzoyl-1,7,12,18-tetrakis(p-tolylsulfonyl)-1,4,7,12,15,18-hexaazacyclodocosane 
• 118852-33-8 4,13-dibenzoyl-1,7,10,16-tetrakis(p-tolylsulfonyl)-1,4,7,10,13,16-hexaazacyclooctadecane 
• 77429-96-0 N'-benzoyl-N,N-bis(p-tolylsulfonyl)diethylenetriamine N,N-disodium salt 
• 77429-92-6 4-benzoyl-1,7-bis(p-tolylsulfonyl)-1,4,7-triazacyclotridecane 
• 77429-91-5 4-benzoyl-1,7-bis(p-tolylsulfonyl)-1,4,7-triazacycloundecane 
• 191986-42-2 Methanesulfonic acid 2-{2-[[2-((2-cyano-ethyl)-{2-[[2-(2-methanesulfonyloxy-ethoxy)-ethyl]-(toluene-4-sulfonyl)-amino]-ethyl}-amino)-ethyl]-(toluene-4-sulfonyl)-amino]-ethoxy}-ethyl ester 
• 191986-40-0 N,N'-{[(2-cyanoethyl)imino]di(ethane-2,1-diyl)}bis[4-methyl-N-(2-{2-[(tetrahydro-2H-pyran-2-yl)oxy]-ethoxy}ethyl)benzenesulfonamide] 
• 191986-41-1 N,N'-{[(2-cyanoethyl)imino]di(ethane-2,1-diyl)}bis{N-[2-(2-hyroxyethoxy)ethyl]4-methylbenzenesulfonamide} 
• 117539-09-0 3-[4,10,16,19,22-Pentakis-(toluene-4-sulfonyl)-1,13-dioxa-4,7,10,16,19,22-hexaaza-cyclotetracos-7-yl]-propionitrile 
• 593284-47-0 7-(N-tosyl-2-aminoethyl)-1,4,10,13,17-pentatosyl-1,4,7,10,13,17-hexaazacycloicosane 

Relevant academic research and scientific papers

Intermolecular hydrogen bonds and the supramolecular structure of N,N′-bis(p-tolylsulfonyl)diethylenetriamine

The title compound N,N′-bis(p-tolylsulfonyl)diethylenetriamine (1) was synthesized and its crystal structure determined by X-ray diffraction. Adjacent molecules of 1, symmetrically related through a c-glide, are linked by alternating hydrogen bonds that f

Hg cathode-free electrochemical detosylation of N,N-disubstituted p-toluenesulfonamides: mild, efficient, and selective removal of N-tosyl group

Hg cathode-free electrochemical detosylation of N,N-disubstituted p-toluenesulfonamides was successfully carried out by a constant current electrolysis using an undivided cell equipped with a platinum cathode and a magnesium anode in the presence of an arene mediator. The deprotection proceeded efficiently and selectively under neutral and mild conditions with a stoichiometric amount of electricity without the use of an Hg cathode to obtain the corresponding secondary amines in good to excellent yields.

New synthetic routes for 1-benzyl-1,4,7,10-tetraazacyclododecane and 1,4,7,10-tetraazacyclododecane-1-acetic acid ethyl ester, important starting materials for metal-coded DOTA-based affinity tags

Two improved routes to synthesize 1-benzyl-1,4,7,10-tetraazacyclododecane (6) and 1,4,7,10-tetraazacyclododecane-1-acetic acid ethyl ester (11) are described as well as the synthesis of 1-{2-[4-(maleimido-N-propylacetamidobutyl) amino]-2-oxoethyl}-1,4,7,10-tetraazacyclododecane-4,7,10-triacetic acid (17) and its Y, Ho, Tm, and Lu complexes. The 1H and 13C NMR spectra of the new compounds as well as the single crystal X-ray structure analyses of the intermediates 4-benzyl-1,7-bis(p-toluenesulfonyl) diethylenetriamine (3) and 1,4,7-tris(p-toluenesulfonyl)diethylenetriamine (7) are reported and discussed. The rare earth complexes of 17 have been characterized by 1H NMR spectroscopy and MALDI-TOF mass spectrometry.

Preparation of hexaaza and heptaaza macrocycles functionalized with a single aminoalkyl pendant arm

A practical and reproducible route for the preparation of 1,4,7,10,13,16,19-heptaazacyclohenicosane (1), 1,4,7,10,13,16-hexaazacyclooctadecane (2), and 1,4,7,10,13,17-hexaazacycloicosane (3) bearing a single N-(2-amino-ethyl) pendant arm has been develope

Synthesis of polyammonium macrocycles with pendant chains

A facile route is described for the synthesis of polyazaoxamacrocycles with pendant chains that is applicable for the preparation of a variety of macrocycles of differing ring size and heteroatom substitution.

Synthesis of Selectively Protected Tri- and Hexaamine Macrocycles

A general route to tri- and hexaamine macrocycles containing selectively protected diethylenetriamine units has been developed.Condensation of the N'-benzoyl-N,N"-bis(p-tolylsulfonyl)diethylenetriamine N,N"-disodium salt with bissulfonate esters of two-, four-, and six-carbon diols at high reactant concentrations gave the corresponding 9- and 18- (85percent and 1percent), 11- and 22- (30percent and 20percent), and 13- and 26- (56percent and 17percent) membered tri- and hexaamine macrocycles, respectively.The benzoyl group was selectively removed with potassium tert-butoxide in ca. 90percent yield, and the macrocycles were conveniently separated by chromatography.Details of the synthetic procedures and characterization of the new selectively protected tri- and hexaamine macrocycles are described.