77442-41-2Relevant academic research and scientific papers
Improved method for preparing penicillanic acid derivatives
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, (2008/06/13)
The present invention relates to a new process for the debromination and/or deiodination of 6,6-dihalo- and 6-monohalopenicillanic acids or derivatives thereof by treatment with dialkyl, trialkyl or diaralkyl phosphite, the desired compounds being obtained in good to excellent yield and in a high state of purity.
Method for preparing 6-β-halopenicillanic acids
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, (2008/06/13)
The present invention relates to a new and improved method for the preparation of a compound of the formula I STR1 in which R stands for halogen, giving rise to high yields of substantially pure 6β-halopenicillanic acids, obtained in one step.
Process for the preparation of penem compounds and intermediates for this preparation
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, (2008/06/13)
Compounds of the general formula I in which, X denotes a halogen atom;, Y denotes a hydrogen atom, a halogen atom, or a moiety of the general formula II Z denotes a halogen atom, a hydroxy group, a substituted hydroxy group, an -S(O)nR5 group, or an -Se(O)mR5 group;, n denotes 0, 1 or 2, preferably 0 or 1;, m denotes 0 or 1;, R3 denotes a hydrogen atom or an organic group;, R4 denotes a hydrogen atom, a carboxy-salt-forming ion, or a carboxy-ester-forming group;, R5 denotes a hydrogen atom, a hydrocarbon group, or a heterocyclyl group; and, R12 denotes a hydrogen atom, an unsubstituted or substituted hydrocarbon group, or an unsubstituted or substituted heterocyclyl group;, are novel intermediates useful in the preparation of 6-methylene-penems of the general formula X:
Derivatives of penicillanic acid
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, (2008/06/13)
This invention relates to penicillanic acid derivatives of the formula I STR1 in which X stands for chlorine, bromine or iodine, to pharmaceutically acceptable, non-toxic salts of the compounds of formula I, to pharmaceutically acceptable, easily hydrolyz
