77444-55-4Relevant academic research and scientific papers
Efficient, "tin-free" radical cyclization to aromatic systems. Synthesis of 5,6,8,9,10,11-hexahydroindolo[2,1-a]isoquinolines
Menes-Arzate, Martha,Martínez, Roberto,Cruz-Almanza, Raymundo,Muchowski, Joseph M.,Osornio, Yazmin M.,Miranda, Luis D.
, p. 4001 - 4004 (2004)
Efficient radical cyclization of alkyl iodides to various aromatic systems including pyrrole, indole, isoquinolone, pyridone, and benzene, mediated by dicumyl peroxide, is described. The methodology was used to provide access to 5,6,8,9,10,11-hexahydroindolo[2,1-a]isoquinoline derivatives.
Radical cyclizations to quinolone and isoquinolone systems under oxidative and reductive conditions
Osornio, Yazmin M.,Miranda, Luis D.,Cruz-Almanza, Raymundo,Muchowski, Joseph M.
, p. 2855 - 2858 (2007/10/03)
Radical cyclizations to quinolone and isoquinolone systems under Fenton-type and n-Bu3SnH-mediated conditions are described. For N-iodoalkylquinolones, ca. 3:1 mixtures of oxidative cyclization products at C-2, and unexpectedly at C-8, were obtained under both conditions. Five- or six-membered oxidative cyclization products were obtained from N-iodoalkylisoquinolones under Fenton-type conditions, whereas n-Bu 3SnH-mediated reactions gave products of reductive cyclization in the five, six, and seven-membered series.
