77448-08-9Relevant academic research and scientific papers
Heterocyclic Prostaglandin Analogues. Part 3. The Relationship of Configuration to Biological Activity for Some Hydantoin Prostanglandin Analogues
Brockwell, Michael A.,Caldwell, A. Gordon,Whittaker, Norman,Begley, Michael J.
, p. 706 - 711 (2007/10/02)
The enantiomers of the two diastereomers of 5-(6-carboxyhexyl)-1-(3-cyclohexyl-3-hydroxypropyl)hydantoin have been synthesised.Potent inhibition of platelet aggregation in this series is associated with the configuration corresponding to that in the natural inhibitors, such as prostaglandins E1 and D2.
