774577-04-7Relevant articles and documents
An efficient synthesis of enantiopure (+)- and (-)-syn-1,3-amino alcohols with a norbornane framework and their application in the asymmetric addition of ZnEt2 to benzaldehyde
De Oliveira, Luciane F.,Costa, Valentim E.U.
, p. 2583 - 2590 (2004)
A series of new optically active (+)- and (-)-syn-1,3-amino alcohols with a norbornane framework has been synthesized. Their abilities as chiral catalysts in the enantioselective additions of ZnEt2 to benzaldehyde were evaluated. High yields and enantiomeric excesses have been achieved (up to 91%). The influence of the configuration of the carbon bearing the hydroxyl group of the ligands has been studied. A plausible mechanism is also suggested for the observed enantioselectivity.
