774577-07-0

Basic information

• Product Name: Bicyclo[2.2.1]heptan-2-ol, 7-(dimethylamino)-, (1S,2S,4S,7R)- (9CI)
• Synonyms: Bicyclo[2.2.1]heptan-2-ol, 7-(dimethylamino)-, (1S,2S,4S,7R)- (9CI)
• CAS NO: 774577-07-0
• Molecular Formula: C9H17NO
• Molecular Weight: 155.23738
• Product Categories: ALCOHOL;CYCLOPENTANE;AMINETERTIARY
• Mol File: 774577-07-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Bicyclo[2.2.1]heptan-2-ol, 7-(dimethylamino)-, (1S,2S,4S,7R)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Bicyclo[2.2.1]heptan-2-ol, 7-(dimethylamino)-, (1S,2S,4S,7R)- (9CI)(774577-07-0)
• EPA Substance Registry System: Bicyclo[2.2.1]heptan-2-ol, 7-(dimethylamino)-, (1S,2S,4S,7R)- (9CI)(774577-07-0)

Safety Data

• Hazardous Substances Data: 774577-07-0(Hazardous Substances Data)

Upstream product

• 774576-93-1 (+)-(1R,2R,4R)-2-exo-hydroxynorbornan-7-one oxime 
• 97858-70-3 (+)-(1S,2R,4R)-2-exo-hydroxynorbornan-7-one 
• 774576-95-3 (+)-(1R,2R,4R)-7-syn-aminonorbornan-2-exo-ol 
• 50-00-0 formaldehyd 
• 5164-69-2 (-)-(1R,2S,4S)-2-exo-hydroxynorbornan-7-one 

Relevant articles and documents

BICYCLO[2.2.1]HEPT-7-YLAMINE DERIVATIVES AND THEIR USES

Compounds of formula (I) have muscarinic M3 receptor modulating activity; Formula(I) wherein A is an oxygen atom or group-N(R12)-;(i) R1 is C1-C6-alkyl or a hydrogen atom; and R2 is a hydrogen atom or a group-R5,-Z-Y-R5-Z-NR9R10;-Z-CO-NR9R 10;-Z-NR9-CO-R5; or-Z-CO2H; and R3 is a lone pair,or C1-C6-aIkyl in which case the nitrogen atom to which it is attached is a quaternary nitrogen and carries a positive charge; or (ii) R1 and R 3 together with the nitrogen to which they are attached form a heterocycloalkyl ring, and R2 is a hydrogen atom; or a group-R5,-Z-Y-R5,-Z-NR9R10,-Z-CO-NR9R10,-Z-NR9-CO-R5 , or-Z-CO2H, in which cases the nitrogen atom to which it is attached is a quaternary nitrogen and carries a positive charge; or (iii) R 1 and R2 together with the nitrogen to which they are attached form a heterocycloalkyl ring, said ring being substituted by a group-Y-R5,-Z-Y-R5,-Z-NR9R 10;-Z-CO-NR9R10;-Z-NR9-CO-R 5; or-Z-CO2H and R3 is a lone pair, or C 1-C6-alkyl in which case the nitrogen atom to which it is attached is a quaternary nitrogen and carries a positive charge; R 4 is a group of formula (a), (b), (c) or (d); is an C1-C6-alkyl, aryl, aryl-fused-cycloalkyl, aryl-fused-heterocycloalkyl, heteroaryl, aryl(C1-C8-alkyl)-, heteroaryl(C1-C8-alkyl)-, cycloalkyl or heterocycloalkyl group, and the remaining variables are as defined in the specification.

An efficient synthesis of enantiopure (+)- and (-)-syn-1,3-amino alcohols with a norbornane framework and their application in the asymmetric addition of ZnEt2 to benzaldehyde

A series of new optically active (+)- and (-)-syn-1,3-amino alcohols with a norbornane framework has been synthesized. Their abilities as chiral catalysts in the enantioselective additions of ZnEt2 to benzaldehyde were evaluated. High yields and enantiomeric excesses have been achieved (up to 91%). The influence of the configuration of the carbon bearing the hydroxyl group of the ligands has been studied. A plausible mechanism is also suggested for the observed enantioselectivity.