77458-34-5Relevant academic research and scientific papers
Synthesis of 1,2,3-triazole and isoxazole-linked pyrazole hybrids and their cytotoxic activity
Madhavilatha,Fatima, Narjis,Sabitha, Gowravaram,Reddy, B. V. Subba,Yadav,Bhattacharjee, Debanjan,Jain, Nishant
, p. 1753 - 1763 (2017)
Abstract: A series of novel 1,2,3-triazole and isoxazole-linked pyrazole derivatives have been synthesized from pyrazole and triazole/isoxazole scaffolds. The synthesized congeners were evaluated for their anti-proliferative efficacy in four cancer cell lines (MCF7, HEPG2, IMR32, and HELA). Majority of the compounds demonstrated potent cytotoxic activities, among them 4k and 4l showed significant cytotoxicity in all the tested cell lines. Graphical Abstract: [InlineMediaObject not available: see fulltext.].
SULFONAMIDE COMPOUNDS FOR THE TREATMENT OF RESPIRATORY DISORDERS
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Page/Page column 29, (2010/08/04)
Compounds of formula (I) are agonists of PPARγ, useful for the treatment of respiratory disease; formula (I): wherein R1, R2 or R3 each independently represents halo, cyano, nitro, amino, alkyl, haloalkyl, alkoxy, haloalkoxy, carboxylic acid or an ester or amide thereof; R4 represents hydrogen or alkyl; m, n or p independently represents 0, 1, 2 or 3.
