77461-97-3

Usage

Uses

Used in Pharmaceutical Industry:
(2,5-dioxotetrahydrofuran-3-yl)acetyl chloride serves as a crucial reagent in organic synthesis, particularly for the preparation of various pharmaceuticals. Its unique structure and reactivity make it valuable in the development of new drugs and medicinal compounds.
Used in Agrochemical Industry:
In addition to its applications in pharmaceuticals, (2,5-dioxotetrahydrofuran-3-yl)acetyl chloride is also utilized in the synthesis of agrochemicals. Its role in this industry is to contribute to the development of effective and innovative products for agricultural use.
Used in Organic Synthesis Research:
(2,5-dioxotetrahydrofuran-3-yl)acetyl chloride plays a significant role in the field of organic synthesis and chemical research. Its properties allow researchers to explore new reactions and pathways, potentially leading to the discovery of novel compounds and materials.

Upstream product

• 4756-10-9 propane-1,2,3-tricarboxylic acid (1,2-anhydride) 
• 99-14-9 tricarallylic acid 

Downstream Products

• 137639-72-6 1-(2,6-Dibromo-2-carboxyphenoxy)formylpropane-2,3-dicarboxylic anhydride 
• 77461-98-4 2-(2,5-Dioxo-tetrahydro-furan-3-yl)-N,N-bis-(2-diphenylphosphanyl-ethyl)-acetamide 
• 77462-03-4 Sodium; 2-{3-[bis-(2-diphenylphosphanyl-ethyl)-carbamoyl]-2-carboxymethyl-propionylamino}-ethanesulfonate 

Relevant academic research and scientific papers

Facile synthesis of (R,R) and of (R,S) tricarballylic acid anhydride and imide derivatives

The diastereomeric mixture of (R)-2-(methoxycarbonylmethyl)-N-(R)-1-(1- phenylethyl) succinimide 11s and (S)-2-(methoxycarbonylmethyl)-N-(R)-1-(1- phenylethyl) succinimide 11a was synthesized by reaction of 2-(carboxymethyl) succinic anhydride 6 with (R)-(α)-methylbenzylamine in dry THF/room temperature/24 hrs. The diastereomeric mixture of 1-[(R)-(α)- Methylbenzylamideformyl)]propane-2,3-dicarboxylic acid anhydride 9s and 1-[(R)-(α)-methylbenzylamideformyl)]propane-2,3-dicarboxylic acid anhydride 9a was isolated as an intermediate under the reaction conditions. This diastereomeric mixture 9s/9a was also prepared by a different route via reaction of 1-(chloroformyl)propane-2,3-dicarboxylic acid anydride 12 with (R)-(α)-methylbenzylamine in the presence of DMA at 0°C for 24 hrs.

Attempted Synthesis of Esters of Tricarballylic Acid and 3,5-Dibromosalicylic Acid. Structure and Properties of Tricarballylic Acid, its Anhydrides and Some of their Derivatives, and an Investigation of the Reaction Pathways of Anhydride Formation by 1H NMR Spectroscopy, MNDO and Mole...

Reactions ordinarily leading to the formation of esters of carboxy acids afford, in the case of tricarballylic acid, the cyclic anhydride.A comparison of the experimental and simulated 1H NMR spectra reveals that the product contains a five-membered ring structure.To explain the experimental findings, theoretical calculations were performed at the level of molecular mechanics and MNDO methods, in order to obtain information on the structure and thermodynamic stability of various substrate conformations and reaction products, as well as on the reaction pathways of anhydride formation.Theoretical predictions reveal that the formation of the five-membered ring structure is preferred in the case of tricarballylic acid anhydride.

Synthesis of Functional Chelating Diphosphines Containing the Bisamino Moiety and the Use of These Materials in the Preparation of Water-Soluble Diphosphine Complexes of Transition Metals

Acylation of bisamine provides a flexible synthesis of functionalized chelating diphosphines.This reaction offers a route to diphosphine complexes of transition metals having a wide range of structures and physical properties and especially to water-soluble complexes.The aqueous solubility of the free ligands and of the complexes prepared from them depend on the ligand, on the metal, and on other materials (especially surfactants) present in the solution.We describe typical preparations of ligands and outline the properties of their complexes with certain transition metals.