774610-01-4

Upstream product

• 1138-80-3 N-(Benzyloxycarbonyl)glycine 
• 113451-59-5 (1S,4S)-2,5-Diaza-bicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester 

Downstream Products

• 1186643-71-9 N-(2-{(1S,4S)-5-[(2S)-2-amino-3,3-dimethylbutanoyl]-2,5-diazabicyclo[2.2.1]hept-2-yl}-2-oxoethyl)-2-chloro-5-(trifluoromethyl)benzenesulfonamide 
• 1186643-69-5 1,1-dimethylethyl [(1S)-2,2-dimethyl-1-({(1S,4S)-5-[({[(phenylmethyl)oxy]carbonyl}amino)acetyl]-2,5-diazabicyclo[2.2.1]hept-2-yl}carbonyl)propyl]carbamate 
• 1186643-68-4 phenylmethyl {2-[(1S,4S)-2,5-diazabicyclo[2.2.1]hept-2-yl]-2-oxoethyl}carbamate 
• 1186643-15-1 N-((1S)-1-{[(1S,4S)-5-({[(2,5-dichlorophenyl)sulfonyl]amino}acetyl)-2,5-diazabicyclo[2.2.1]hept-2-yl]carbonyl}-2,2-dimethylpropyl)-5-fluoro-1H-indole-2-carboxamide 
• 1186643-79-7 phenylmethyl [2-((1S,4S)-5-{(2S)-2-[(1H-indol-2-ylcarbonyl)amino]-3,3-dimethylbutanoyl}-2,5-diazabicyclo[2.2.1]hept-2-yl)-2-oxoethyl]carbamate 
• 1186643-38-8 N-[(1S)-1-({(1S,4S)-5-[({[5-chloro-2-(methyloxy)phenyl]sulfonyl}amino)acetyl]-2,5-diazabicyclo[2.2.1]hept-2-yl}carbonyl)-2,2-dimethylpropyl]-1H-indole-2-carboxamide 
• 1186643-85-5 C₂₁H₃₀N₄O₄ 
• 1186643-78-6 N-(2-{(1 S,4S)-5-[(2S)-2-amino-3,3-dimethylbutanoyl]-2,5-diazabicyclo[2.2.1]hept-2-yl}-2-oxoethyl)-2-chloro-5-(trifluoromethyl)benzenesulfonamide 
• 1186643-37-7 N-[(1S)-1-({(1S,4S)-5-[({[2-chloro-5-(trifluoromethyl)phenyl]sulfonyl}amino)acetyl]-2,5-diazabicyclo[2.2.1]hept-2-yl}carbonyl)-2,2-dimethylpropyl]-1-benzothiophene-2-carboxamide 
• 1198297-69-6 2-chloro-N-[2-((1S,4S)-5-{[(4R)-3-(1H-indol-2-ylcarbonyl)-5,5-dimethyl-1,3-thiazolidin-4-yl]carbonyl}-2,5-diazabicyclo[2.2.1]hept-2-yl)-2-oxoethyl]-5-(trifluoromethyl)benzenesulfonamide 
• 1198297-79-8 2-chloro-N-[2-((1S,4S)-5-{[(4R)-5,5-dimethyl-1,3-thiazolidin-4-yl]carbonyl}-2,5-diazabicyclo[2.2.1]hept-2-yl)-2-oxoethyl]-5-(trifluoromethyl)benzenesulfonamide 
• 1198297-75-4 2-chloro-N-{2-[(1S,4S)-2,5-diazabicyclo[2.2.1]hept-2-yl]-2-oxoethyl}-5-(trifluoromethyl)benzenesulfonamide 
• 774610-02-5 1,1-dimethylethyl (1S,4S)-5-[2-({[benzyloxy]carbonyl}amino)ethyl]-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate 

Relevant academic research and scientific papers

TRPV4 ANTAGONISTS

The present invention relates to diazabicyclo[2.2.1 ]hept-2-yl analogs, pharmaceutical compositions containing them and their use as TRPV4 antagonists.

TRPV4 ANTAGONISTS

The present invention relates to diazabicyclo[2.2.1 ]hept-2-yl analogs, pharmaceutical compositions containing them and their use as TRPV4 antagonists.

ANTIBACTERIAL AGENTS

Quinoline and naphthyridine derivatives useful in the treatment of bacterial infections in mammals, particularly humans.