77464-06-3

Usage

InChI:InChI=1/C9H20N2O/c1-7(2)5-11(9(10)12)6-8(3)4/h7-8H,5-6H2,1-4H3,(H2,10,12)

Upstream product

• 60-29-7 diethyl ether 
• 64-17-5 ethanol 
• 62384-21-8 isovaleryl azide 
• 590-28-3 potassium cyanate 
• 18251-82-6 diisobutylamine hydrochloride 
• 1531-37-9 N-cyanodiisobutylamine 
• 110-96-3 diisobutylamine 
• 1189-71-5 isocyanate de chlorosulfonyle 
• 57-13-6 urea 

Downstream Products

• 81994-74-3 N-benzoyl-N',N'-diisobutylurea 

Relevant academic research and scientific papers

METHOD FOR PRODUCING META-XYLYLENEDIISOCYANATES

A method for producing meta-xylylenediisocyanates includes a reaction step in which monohalogenated benzenes, formaldehydes, and an amide compound represented by general formula (1) below are allowed to react in the presence of an acidic liquid to produce a bisamide compound; a dehalogenation step in which in the bisamide compound, the halogen atom derived from the monohalogenated benzenes is replaced with a hydrogen atom; and a thermal decomposition step in which the bisamide compound from which the halogen atom is eliminated is subjected to thermal decomposition. In the reaction step, the acidic liquid contains inorganic acid, the equivalent ratio of the hydrogen atom of the inorganic acid relative to the monohalogenated benzenes is more than 14, the acidic liquid has an inorganic acid concentration of more than 90 mass %, and the reaction temperature is more than 10° C. [in-line-formulae]General formula (1):[/in-line-formulae] wherein R1 represents an alkoxy group or an amino group.

METHOD FOR PRODUCING M-XYLYLENE DIISOCYANATE

A method for producing meta-xylylenediisocyanates includes a reaction step in which monohalogenated benzenes, formaldehydes, and an amide compound represented by general formula (1) below are allowed to react in the presence of an acidic liquid to produce a bisamide compound; a dehalogenation step in which in the bisamide compound, the halogen atom derived from the monohalogenated benzenes is replaced with a hydrogen atom; and a thermal decomposition step in which the bisamide compound from which the halogen atom is eliminated is subjected to thermal decomposition. In the reaction step, the acidic liquid contains inorganic acid, the equivalent ratio of the hydrogen atom of the inorganic acid relative to the monohalogenated benzenes is more than 14, the acidic liquid has an acid concentration of more than 90 mass%, and the reaction temperature is more than 10°C. General formula (1): (in general formula (1), R 1 represents an alkoxy group or an amino group).

Protease inhibitors

The present invention provides compounds of formula (I) which inhibit proteases, including cathepsin K, pharmaceutical compositions of such compounds, and methods for treating diseases of excessive bone loss or cartilage or matrix degradation, including osteoporosis; gingival disease including gingivitis and periodontitis; arthritis, more specifically, osteoarthritis and rheumatoid arthritis; Paget's disease; hypercalcemia or malignancy; and metabolic bone disease therewith.

Some Extensions of von Braun (BrCN) Reaction on Organic Bases, Part IV

Extensions of von Braun cyanogen bromide reaction have been undertaken on some aliphatic and heterocyclic amines.Monocyanamides of all these bases yielded their respective urea and carboxamide derivatives on hydrolysis with dilute hydrochloric acid.They also gave the amido derivatives on reaction with Zn/HCl, as in the case of diisobutyl and di-2-butyl cyanamides. - Key words: von Braun Cyanogen Bromide Reaction

Some Extensions of von Braun (BrCN) Reaction on Organic Bases, Part III

In continuation of studies on some extensions of von Braun BrCN reaction on organic bases, work on diisobutylamine and di-2-butylamine, has led to various substituted ureas and N-imino-ethyl ether derivatives.In contrast to previous observations, reduction of their cyanamides with Zink/HCl gave the amido derivatives instead of diamines. - Key words: von Braun Cyanogen Bromide Reaction